2. Apoptosis
  3. Apoptosis Ferroptosis
  4. α-Eleostearic acid

α-Eleostearic acid  (Synonyms: cis-Eleostearic acid)

Cat. No.: HY-27787 Purity: ≥97.0%
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α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity.

For research use only. We do not sell to patients.

α-Eleostearic acid Chemical Structure

α-Eleostearic acid Chemical Structure

CAS No. : 506-23-0

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1 mg USD 55 In-stock
5 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

α-Eleostearic acid Related Antibodies

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Description

α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity[1][2][3].

In Vitro

α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma[1].
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells[1].
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Eleostearic acid Related Antibodies
In Vivo

α-Eleostearic acid (0.5% of total lipid given; p.o.) inhibits Sodium Arsenite-induced oxidative stress, including reversal of antioxidant enzyme activity and reduction of lipid peroxidation levels[2].
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

278.43

Formula

C18H30O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O
Shipping

Shipping with dry ice.
Storage

-80°C
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (107.75 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5916 mL 17.9578 mL 35.9157 mL
5 mM 0.7183 mL 3.5916 mL 7.1831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (238 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5916 mL 17.9578 mL 35.9157 mL 89.7892 mL
5 mM 0.7183 mL 3.5916 mL 7.1831 mL 17.9578 mL
10 mM 0.3592 mL 1.7958 mL 3.5916 mL 8.9789 mL
15 mM 0.2394 mL 1.1972 mL 2.3944 mL 5.9859 mL
20 mM 0.1796 mL 0.8979 mL 1.7958 mL 4.4895 mL
25 mM 0.1437 mL 0.7183 mL 1.4366 mL 3.5916 mL
30 mM 0.1197 mL 0.5986 mL 1.1972 mL 2.9930 mL
40 mM 0.0898 mL 0.4489 mL 0.8979 mL 2.2447 mL
50 mM 0.0718 mL 0.3592 mL 0.7183 mL 1.7958 mL
60 mM 0.0599 mL 0.2993 mL 0.5986 mL 1.4965 mL
80 mM 0.0449 mL 0.2245 mL 0.4489 mL 1.1224 mL
100 mM 0.0359 mL 0.1796 mL 0.3592 mL 0.8979 mL
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α-Eleostearic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Eleostearic acid506-23-0cis-Eleostearic acidApoptosisFerroptosisconjugated linolenic acidantioxidantantitumorInhibitorinhibitorinhibit

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