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Results for "

slices

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (1) Amyloid-β (2) Apoptosis (1) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Enterovirus (1) Fluorescent Dye (3) HCN Channel (1) Histamine Receptor (1) iGluR (3) Keap1-Nrf2 (1) mGluR (1) Monoamine Oxidase (1) Monoamine Transporter (1) nAChR (2) PACAP Receptor (2) Potassium Channel (1) Reactive Oxygen Species (1) Sodium Channel (1) Tyrosinase (1) Virus Protease (1)
By Research Areas:	Cancer (1) Endocrinology (3) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (17)

By Targets:

Adenosine Receptor (1)

Adrenergic Receptor (1)

Amyloid-β (2)

Apoptosis (1)

Biochemical Assay Reagents (1)

Cannabinoid Receptor (1)

Enterovirus (1)

Fluorescent Dye (3)

HCN Channel (1)

Histamine Receptor (1)

iGluR (3)

Keap1-Nrf2 (1)

mGluR (1)

Monoamine Oxidase (1)

Monoamine Transporter (1)

nAChR (2)

PACAP Receptor (2)

Potassium Channel (1)

Reactive Oxygen Species (1)

Sodium Channel (1)

Tyrosinase (1)

Virus Protease (1)

By Research Areas:

Cancer (1)

Endocrinology (3)

Infection (1)

Inflammation/Immunology (4)

Metabolic Disease (1)

Neurological Disease (17)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1388

β-Amyloid (1-42), (rat/mouse) 1 Publications Verification Amyloid β-peptide (1-42) (rat/mouse)	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-P1388A

β-Amyloid (1-42), (rat/mouse) (TFA) 1 Publications Verification Amyloid β-peptide (1-42) (rat/mouse) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-119615

Mezilamine	Adrenergic Receptor	Neurological Disease Endocrinology
Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of ³H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist .

HY-103465

FFN511	Monoamine Transporter	Others
FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC₅₀ of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices .

HY-155524

Anticancer agent 134	Apoptosis	Cancer
Anticancer agent 134 (compound 6a) is a environment-sensitive fluorescent probe and an apoptosis inducer, making a distinction between the tumor and normal tissues. Anticancer agent 134 localizes to the nuclear bodies in tumor slices .

HY-W342930

Bordeaux Red Acid Red 17	Biochemical Assay Reagents	Others
Bordeaux Red (Acid Red 17) is a redox indicator that can be used for cytoplasm staining, such as spleen, testis, and liver slice staining. Bordeaux Red is a kind of biological materials or organic compounds that are widely used in life science research .

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride	Others	Inflammation/Immunology
Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.

HY-101878

Texas Red 3 Publications Verification Sulforhodamine 101; SR101	Fluorescent Dye	Neurological Disease
Texas Red (Sulforhodamine 101) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations .

HY-D1426

Di-12-ANEPPQ	Fluorescent Dye	Neurological Disease
Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus .

HY-157786

XPC-5462	Sodium Channel	Neurological Disease
XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC₅₀s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model .

HY-107605

UBP296	iGluR	Neurological Disease
UBP296 is a potent and selective antagonist of GLU_K5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices .

HY-D2155

Texas red-X 4-succinimidyl ester	Fluorescent Dye	Others
Texas red-X 4-succinimidyl ester is a derivative of Texas Red (HY-101878), an amphoteric rhodamine red fluorescent dye. Texas Red is widely used to study neuronal morphology and as a cell type-selective fluorescent marker for astrocytes, both in vivo and in slice preparations.

HY-163455

pan-HCN-IN-1	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-103188

PD81723	Adenosine Receptor	Neurological Disease
PD81723 is an adenosine receptor binding enhancer. PD81723 enhances the inhibition of exogenous adenosine in a dose-dependent manner in hippocampal brain sections .

HY-107761

JMV 390-1	Others	Neurological Disease
JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC₅₀ values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium .

HY-117764

LSP4-2022	mGluR	Neurological Disease
LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC₅₀ of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity .

HY-106161

Rupintrivir 5 Publications Verification AG7088	Virus Protease Enterovirus	Infection Inflammation/Immunology
Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-158235

Tyrosinase-IN-27	Tyrosinase	Others
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC₅₀: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices. .

HY-106076

REV 2871 Eclazolast; CHBZ	Histamine Receptor	Inflammation/Immunology
REV 2871 (Eclazolast; CHBZ) is a potent and oral activity antiallergic agent. REV 2871 also is an irreversibility histamine release (HR) inhibitor .

HY-144635

Nrf2-ARE/hMAO-B/QR2 modulator 1	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices .

HY-10932

Aniracetam Ro 13-5057	nAChR iGluR	Neurological Disease
Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO₂-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders .

HY-103331

COR170	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a K_i value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection .

HY-P0221B

PACAP (1-38) free acid TFA	PACAP Receptor	Endocrinology
PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P0221C

PACAP (1-38) free acid	PACAP Receptor	Endocrinology
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-10932R

Aniracetam (Standard)	nAChR iGluR	Neurological Disease
Aniracetam (Standard) is the analytical standard of Aniracetam. This product is intended for research and analytical applications. Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO₂-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders .

HY-100743

DL-AP4 2-Amino-4-phosphonobutyric acid	Others	Neurological Disease Metabolic Disease
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent K_d of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .

Texas Red 3 Publications Verification Sulforhodamine 101; SR101	Fluorescent Dyes/Probes
Texas Red (Sulforhodamine 101) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations .

Di-12-ANEPPQ	Fluorescent Dyes/Probes
Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus .

Texas red-X 4-succinimidyl ester	Fluorescent Dyes/Probes
Texas red-X 4-succinimidyl ester is a derivative of Texas Red (HY-101878), an amphoteric rhodamine red fluorescent dye. Texas Red is widely used to study neuronal morphology and as a cell type-selective fluorescent marker for astrocytes, both in vivo and in slice preparations.

Bordeaux Red Acid Red 17	Indicators
Bordeaux Red (Acid Red 17) is a redox indicator that can be used for cytoplasm staining, such as spleen, testis, and liver slice staining. Bordeaux Red is a kind of biological materials or organic compounds that are widely used in life science research .

Cat. No.	Product Name	Target	Research Area