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Interleukin-4 (IL-4) is a multipotent cytokine involved in the regulation of immune response. IL-4 is secreted mainly by mast cells, T cells, eosinophils and basophils, and is the receptor of IL-4 RA[1]. The effect of IL-4 depends on the type of shared receptor gamma chain (γc) that its receptor IL-4 RA recruits. IL-2Rγ is a common subunit of several interleukin receptors. (1) IL-4 RA recruits IL-2Rγ and forms a Type I signaling complex with IL-4 expressed on hematopoietic cells, leading to a series of receptor-related kinase-mediated phosphorylation events. More importantly, IL-2Rγ is also involved in the stimulating effect of IL-15 on neutrophil phagocytosis. Moreover, the IL-4 receptor complex further leads to recruitment of mediators for cell growth, anti-apoptosis, gene activation, and differentiation. However, (2) IL-4 RA recruits the IL-13RA1 chain and forms a Type II complex expressed on non-hematopoietic cells. It may stimulate autophagy of dendritic cells by interfering with mTORC1 signaling pathway and inducing RUFY4. In addition, IL-13RA1 plays a vital role in higher functions of the normal brain, such as memory and learning[2][3].
Specifically, IL-4 is involved in regulating the differentiation of antigen-stimulated naive T cells to produce IL-4 and other cytokines, including IL-5, IL-10, and IL-13. At the same time, it also inhibits the appearance of CD4+ of IFN-γ producing cells and prolongs the life of T and B lymphocytes under culture conditions. Secondly, IL-4 also controls immunoglobulin conversion and is involved in allergic regulation. It determines the conversion of human B cells to express IgE and IgG4, or mouse B cells to express IgE and IgG1. IL-4 also increases the expression of Class II MHC molecules and CD23 in B cells to participate in the immune response. IL-4 also plays an important role in tissue adhesion and inflammation. In conjunction with TNF, it induces the expression of vascular endothelial cell adhesion molecule-1 (VCAM-11) on vascular endothelial cells and down-regulates the selectin. IL-4 also plays a protective immune role induced by worms and other extracellular parasites[1].
IL-4 Protein, Mouse (CHO) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.
GMP IL-4 Protein, Human (HEK293) is a recombinant GMP-grade protein produced by HEK293 cells with C-His tag. IL-4 is an anti-inflammatory cytokine acting as a pleiotropic regulator of numerous immune and inflammatory processes.
IL-4 Protein, Human (CHO) is a CHO cell derived, potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.
IL-4 Protein, Mouse (HEK293, His) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 Protein, Mouse (HEK293, His) is a recombinant mouse interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.
IL-4 Protein, Human (HEK293) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells.
IL-4 Protein, Human (HEK293, His) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293, His) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.
Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. IL-4 Protein, Mouse (Q136D, Y139D, sf9, His) is the recombinant mouse-derived IL-4 protein, expressed by Sf9 insect cells , with C-His labeled tag and Q136D, Y139D, , , mutation. The total length of IL-4 Protein, Mouse (Q136D, Y139D, sf9, His) is 140 a.a., with molecular weight of ~19 kDa.
The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) is 129 a.a., with molecular weight of 23-25 kDa.
The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. GMP IL-4 Protein, Human is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free. The total length of GMP IL-4 Protein, Human is 129 a.a., with molecular weight of ~15.6 kDa.
The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. Animal-Free IL-4 Protein, Human (His) is the recombinant human-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Human (His) is 129 a.a., with molecular weight of ~15.9 kDa.
Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. Animal-Free IL-4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Mouse (His) is 120 a.a., with molecular weight of ~14.5 kDa.
IL-4 Protein, Mouse (HEK293) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.
IL-4 Protein, Mouse is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression.
IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-4 Protein, Cynomolgus (HEK293, His) is 129 a.a., with molecular weight of 23-28 kDa.
IL-4 Protein, Porcine (CHO) is the prime anti-infalmmatory cytokine involves in cell proliferation, various gene expression and avert apoptosis in IL-4 expressing cells.
The IL-4 protein actively participates in the B cell activation process, acting as a costimulator for DNA synthesis. It induces the expression of class II MHC molecules on resting B cells, enhances IgE and IgG1 secretion and cell surface expression, and modulates CD23 expression on lymphocytes and monocytes. IL-4 Protein, Canine is the recombinant canine-derived IL-4 protein, expressed by E. coli , with N-Met labeled tag. The total length of IL-4 Protein, Canine is 108 a.a., with molecular weight of 12-14 kDa.
IL-4 protein actively engages in B-cell activation, serving as a costimulator for DNA synthesis, inducing class II MHC molecule expression, and enhancing IgE and IgG1 secretion. It regulates CD23 expression on lymphocytes and monocytes, positively influences IL31RA expression in macrophages, and induces autophagy in dendritic cells through mTORC1 signaling interference and RUFY4 induction. IL-4 Protein, Rhesus macaque is the recombinant Rhesus Macaque-derived IL-4 protein, expressed by E. coli , with tag free. The total length of IL-4 Protein, Rhesus macaque is 129 a.a., with molecular weight of ~14.9 kDa.
The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IL-4 Protein, Human (HEK293, His-Avi) is 129 a.a., with molecular weight of 23-25 kDa.
Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. IL-4 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived IL-4 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of IL-4 Protein, Mouse (HEK293, C-His) is 120 a.a., with molecular weight of ~18 kDa.
