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Results for "

ceramidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ceramidase (7) Apoptosis (1) Biochemical Assay Reagents (1) FAAH (1) Fluorescent Dye (2) Glucosylceramide Synthase (GCS) (1) Glutathione Peroxidase (1) iGluR (1) LPL Receptor (1) Nucleoside Antimetabolite/Analog (1) Phospholipase (2) SARS-CoV (1) Virus Protease (1)
By Research Areas:	Cancer (12) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Targets Recommended: Ceramidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153396

*Acid Ceramidase-IN-2*	Ceramidase	Cancer
Acid Ceramidase-IN-2 (compound 1) is an acid *ceramidase* inhibitor with potentially antiproliferative and cytostatic activities. Moreover, human acid ceramidase is overexpressed in prostate cancer cells, indicating potential anti-tumor effect of Acid Ceramidase-IN-2. And Acid Ceramidase-IN-2 hydrolysis can be inhibited by 3 a-ketoamides GT85, GT98 and GT99 inhibits in vitro .

HY-141866

*Acid Ceramidase-IN-1*	Ceramidase	Neurological Disease
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC₅₀=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice .

HY-103359

Ceranib1	Ceramidase	Cancer
Ceranib1 is a *ceramidase* inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells .

HY-141577

C12-NBD Sphinganine	Biochemical Assay Reagents	Others
C12-NBD Sphinganine is a fluorescent *ceramidase* substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

HY-141575

C12-NBD-ceramide

Fluorescent Dye Others

C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

C12-NBD-ceramide	Fluorescent Dye	Others
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

HY-163106

W000113414_I13	Ceramidase	Cancer
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC₅₀ value of 6.6?μM. W000113414_I13 can be used for the research of cancer .

HY-124962

D-NMAPPD (1R,2R)-B13	iGluR	Neurological Disease Cancer
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-103593A

LCL521 dihydrochloride 1 Publications Verification	Phospholipase	Cancer
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .

HY-103593

LCL521

1 Publications Verification

Phospholipase Cancer

LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .
HY-137422

D-erythro-MAPP

1 Publications Verification

D-e-MAPP
Ceramidase Neurological Disease Cancer

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC₅₀ of 1-5 μM in vitro .
HY-124927

ARN14988

Others Cancer

ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC₅₀=12.8 nM for the human enzyme) .

LCL521 1 Publications Verification	Phospholipase	Cancer
LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .

D-erythro-MAPP 1 Publications Verification D-e-MAPP	Ceramidase	Neurological Disease Cancer
D-erythro-MAPP (D-e-MAPP) is a *ceramidase* inhibitor, with an IC₅₀ of 1-5 μM in vitro .

ARN14988	Others	Cancer
ARN14988 is a potent inhibitor of *acid ceramidase* (ACDase) (IC₅₀**=12.8 nM for the human enzyme) .

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid *ceramidase* inhibitor that inhibits cellular *ceramidase* activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .

HY-103592

ARN14974

Ceramidase Cancer

ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC₅₀=79 nM) .
HY-D1582

C12 NBD Phytoceramide

Fluorescent Dye Others

C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

ARN14974	Ceramidase	Cancer
ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC₅₀=79 nM) .

C12 NBD Phytoceramide	Fluorescent Dye	Others
C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

HY-B0182

Carmofur 3 Publications Verification HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-B0182R

Carmofur (Standard)		Infection Inflammation/Immunology Cancer
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

C12-NBD Sphinganine	Dyes
C12-NBD Sphinganine is a fluorescent *ceramidase* substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

C12-NBD-ceramide	Fluorescent Dyes/Probes
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

C12 NBD Phytoceramide	Chromogenic Substrates
C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

Species:	Human (1) Mouse (1)
Tag:	SUMO (1) His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71541

	ASAH1 Protein, Human (His-SUMO) AC; ACDase; Acid CDase; Acid ceramidase; Acid ceramidase precursor; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH 1; ASAH; ASAH1; ASAH1_HUMAN; FLJ21558; FLJ22079; N acylsphingosine amidohydrolase (acid ceramidase) 1; N acylsphingosine amidohydrolase 1	Human	E. coli
	ASAH1 is a lysosomal ceramidase that critically regulates sphingolipid metabolism by hydrolyzing ceramide into sphingosine and fatty acids at acidic pH. Bioactive lipids—ceramide, sphingosine, and sphingosine-1-phosphate—control signaling pathways for cell proliferation, apoptosis, and differentiation. ASAH1 Protein, Human (His-SUMO) is the recombinant human-derived ASAH1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of ASAH1 Protein, Human (His-SUMO) is 374 a.a., with molecular weight of ~58.7 kDa.

HY-P76735

	ASAH2 Protein, Mouse (HEK293, His) 1 Publications Verification Neutral ceramidase; N-Cdase; Acylsphingosine deacylase 2	Mouse	HEK293
	ASAH2 protein has N-acylsphingosine amide hydrolase activity, which is essential for lipid digestion and sphingolipid metabolism. It is present in different cellular compartments, highlighting its versatility. ASAH2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ASAH2 protein, expressed by HEK293 , with N-His labeled tag. The total length of ASAH2 Protein, Mouse (HEK293, His) is 723 a.a., with molecular weight of 105-115 kDa.


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