Search Result

Pathways Recommended:	Neuronal Signaling PI3K/Akt/mTOR JAK/STAT Signaling

Results for "

mTOR signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mTOR (48) 5-HT Receptor (11) Akt (18) AMPK (6) Antibiotic (2) Apoptosis (32) ASCT (1) ATP Synthase (2) Autophagy (20) Bacterial (8) Bcl-2 Family (4) Beclin1 (2) Caspase (2) COX (1) DNA-PK (2) DNA/RNA Synthesis (2) Dopamine Receptor (4) EGFR (1) Endogenous Metabolite (18) ERK (1) FAK (2) Fungal (2) Glutaminase (1) Hedgehog (2) HIF/HIF Prolyl-Hydroxylase (3) HSP (1) HSV (1) IGF-1R (1) Influenza Virus (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (4) JNK (1) Keap1-Nrf2 (2) MDM-2/p53 (1) Microtubule/Tubulin (1) MMP (1) Necroptosis (1) NF-κB (5) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) Parasite (2) PARP (1) PDK-1 (1) PI3K (14) Pim (2) PINK1/Parkin (2) PPAR (2) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (2) Reactive Oxygen Species (5) ROR (1) SphK (1) STAT (2) TNF Receptor (1) Topoisomerase (1) VEGFR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (4) Endocrinology (3) Infection (10) Inflammation/Immunology (9) Metabolic Disease (24) Neurological Disease (12)

By Targets:

mTOR (48)

5-HT Receptor (11)

Akt (18)

AMPK (6)

Antibiotic (2)

Apoptosis (32)

ASCT (1)

ATP Synthase (2)

Autophagy (20)

Bacterial (8)

Bcl-2 Family (4)

Beclin1 (2)

Caspase (2)

COX (1)

DNA-PK (2)

DNA/RNA Synthesis (2)

Dopamine Receptor (4)

EGFR (1)

Endogenous Metabolite (18)

ERK (1)

FAK (2)

Fungal (2)

Glutaminase (1)

Hedgehog (2)

HIF/HIF Prolyl-Hydroxylase (3)

HSP (1)

HSV (1)

IGF-1R (1)

Influenza Virus (1)

Integrin (1)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

JNK (1)

Keap1-Nrf2 (2)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

MMP (1)

Necroptosis (1)

NF-κB (5)

NO Synthase (1)

Nuclear Hormone Receptor 4A/NR4A (1)

Parasite (2)

PARP (1)

PDK-1 (1)

PI3K (14)

Pim (2)

PINK1/Parkin (2)

PPAR (2)

Prolyl Endopeptidase (PREP) (2)

Prostaglandin Receptor (2)

Reactive Oxygen Species (5)

ROR (1)

SphK (1)

STAT (2)

TNF Receptor (1)

Topoisomerase (1)

VEGFR (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (60)

Cardiovascular Disease (4)

Endocrinology (3)

Infection (10)

Inflammation/Immunology (9)

Metabolic Disease (24)

Neurological Disease (12)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: mTOR RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163199

ASCT2-IN-2	ASCT mTOR Apoptosis Autophagy	Cancer
ASCT2-IN-2 (compound 25e) is an ASCT2 inhibitor with IC₅₀ of 5.14 μM. ASCT2-IN-2 regulates amino acid metabolism as well as mTOR signaling and thereby induces cell apoptosis. ASCT2-IN-2 inhibits tumor growth .

HY-112055

DIM-C-pPhOH 4 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively .

HY-N0486

L-Leucine 5+ Cited Publications Leucine	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the *mTOR* signaling pathway .

HY-137996

Dehydrovomifoliol	Akt mTOR	Metabolic Disease
Dehydrovomifoliol is a *AKT/mTOR* dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Keap1-Nrf2 mTOR Apoptosis	Cancer
Sarmentosin is an activator of Nrf2. Sarmentosin inhibits *mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-N0112

Dihydromyricetin 10+ Cited Publications Ampelopsin; Ampeloptin	mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting *mTOR* signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-119767

Jolkinolide A	VEGFR Apoptosis	Cancer
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the *Akt-STAT3-mTOR* signaling pathway and reduces the expression of VEGF in A549 cells .

HY-N0486S13

L-Leucine-15N,d10

mTOR Endogenous Metabolite Metabolic Disease

L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

L-Leucine-15N,d10	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S11

L-Leucine-d1	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-147613

PI3K/mTOR Inhibitor-6	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent and dual inhibitor of *PI3K/mTOR*. PI3K/mTOR Inhibitor-6 displays better stability in artificial gastric fluids than gedatolisib. PI3K/mTOR Inhibitor-6 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-6 has the potential for the research of cancer diseases .

HY-151622

PI3K/mTOR Inhibitor-11	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-11 is an orally active *PI3K/mTOR* inhibitor (IC₅₀: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers .

HY-N0486S

L-Leucine-d10	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N4176

Ginkgolide K	Autophagy	Neurological Disease
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-N0486S4

L-Leucine-d7	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S9

L-Leucine-d3	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S12

L-Leucine-d2	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S2

L-Leucine-13C6	mTOR Endogenous Metabolite	Metabolic Disease
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S1

L-Leucine-13C	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S3

L-Leucine-15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].

HY-N0486S10

L-Leucine-18O2	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-147614

PI3K/mTOR Inhibitor-7	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of *PI3K/mTOR*. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC₅₀ values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases .

HY-16962

CC-115 1 Publications Verification	DNA-PK mTOR	Cancer
CC-115 is a potent and dual DNA-PK and *mTOR* kinase inhibitor with IC₅₀s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

HY-16962A

CC-115 hydrochloride 1 Publications Verification	DNA-PK mTOR	Cancer
CC-115 hydrochloride is a potent and dual DNA-PK and *mTOR* kinase inhibitor with IC₅₀s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

HY-N0486S5

L-Leucine-2-13C	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-115449

Chromeceptin 94G6	IGF-1R Akt mTOR	Cancer
Chromeceptin (94G6) is an *IGF signaling* pathway** inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .

HY-N10093

Chamaejasmine Chamaejasmin	Apoptosis AMPK Autophagy Reactive Oxygen Species	Cancer
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-130723

AMPK activator 2	AMPK	Cancer
AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-130723A

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-N0047

Polyphyllin I 1 Publications Verification	JNK mTOR Akt PDK-1 Autophagy Apoptosis	Cancer
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of *PDK1/Akt/mTOR* signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .

HY-N0109

Salidroside Maximum Cited Publications 21 Publications Verification Rhodioloside	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)	Cancer
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating *mTOR* signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-131015

HaXS8	Others	Others
HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling .

HY-N0486S8

L-Leucine-13C6,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N6843

Arnicolide D 1 Publications Verification	Caspase PI3K Akt mTOR STAT	Cancer
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the *PI3K/AKT/mTOR* and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .

HY-N6626

Pyraclostrobin	Fungal Bacterial Bcl-2 Family Autophagy Beclin1 AMPK mTOR	Infection Metabolic Disease
Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of *AMPK/mTOR* signaling. Pyraclostrobin can be used to control crop diseases .

HY-N0486S6

L-Leucine-2-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S7

L-Leucine-1-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-162141

MD102	Glutaminase Apoptosis	Cancer
MD102 is a potent TG2 inhibitor with an IC₅₀ value of 0.35 μM. MD102 stabilizes p53 by inhibiting TG2, inducing a decrease in p-AKT and p-mTOR downstream signaling, leading to tumor cell apoptosis .

HY-N2602

Sanggenol L	MDM-2/p53	Cancer
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of *PI3K/Akt/mTOR* signaling and cell cycle arrest via activation of p53 in p

HY-N1338

Royleanone NSC 122417	mTOR Akt	Cancer
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits *mTOR/PI3/AKT* signaling pathway in LNCaP prostate cancer cells .

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-N0279

Cardamonin 5+ Cited Publications Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit *mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-146738

GSD-11	Akt	Cancer
GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].

HY-162143

SKI-349	SphK Akt mTOR	Cancer
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells .

HY-W019868

1-O-Hexadecyl-2-O-acetyl-sn-glycerol	Others	Others
1-O-Hexadecyl-2-O-acetyl-sn-glycerol is an alkyl acylglycerol that may activate the amino acid transport activity of the A-system and stimulate the absorption of methylaminoisobutyric acid (MeAIB). MeAIB inhibits mTOR phosphorylation, which may affect intestinal amino acid absorption and signal transduction .

HY-P10323

T7 Peptide Tumstatin (74-98), human	Integrin FAK mTOR Apoptosis	Cancer
T7 peptide is an endothelial cell-specific inhibitor. T7 peptide interacts with αVβ3 integrin to inhibit the FAK, PI3-kinase, PKB/Akt, and mTOR/ signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis .

HY-132168

RMC-5552 1 Publications Verification	mTOR	Cancer
RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC₅₀s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC₅₀ of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity .

HY-N2590

Lupenone	Parasite PI3K Akt mTOR NF-κB	Infection Inflammation/Immunology Cancer
Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the *PI3K/Akt/mTOR* and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities .

HY-N6950

Hederacolchiside A1 1 Publications Verification	PI3K Akt mTOR Parasite Apoptosis	Infection Cancer
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating *PI3K/Akt/mTOR* signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

HY-N6626R

Pyraclostrobin (Standard)	Fungal Bacterial Bcl-2 Family Autophagy Beclin1 AMPK mTOR	Infection Metabolic Disease
Pyraclostrobin (Standard) is the analytical standard of Pyraclostrobin. This product is intended for research and analytical applications. Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of *AMPK/mTOR* signaling. Pyraclostrobin can be used to control crop diseases .

Cat. No.	Product Name

HY-L015

PI3K/Akt/mTOR Compound Library

587 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 587 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

HY-L074

Anti-Breast Cancer Compound Library

1,985 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 1,985 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

HY-L124

Anti-Prostate Cancer Compound Library

2,332 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 2,332 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L101

Anti-Liver Cancer Compound Library

1,846 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 1,846 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0486

L-Leucine 5+ Cited Publications Leucine	Structural Classification Zea mays L. Classification of Application Fields Anti-aging Source classification Metabolic Disease Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Gramineae Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder	mTOR Endogenous Metabolite
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the *mTOR* signaling pathway .

HY-N0112

Dihydromyricetin 10+ Cited Publications Ampelopsin; Ampeloptin	Infection Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting *mTOR* signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-137996

Dehydrovomifoliol	Artemisia frigida Willd. Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Akt mTOR
Dehydrovomifoliol is a *AKT/mTOR* dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Structural Classification Natural Products Animals Source classification Saccharides Monosaccharides	Keap1-Nrf2 mTOR Apoptosis
Sarmentosin is an activator of Nrf2. Sarmentosin inhibits *mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-119767

Jolkinolide A	Structural Classification Euphorbia fischeriana Steud. Terpenoids Source classification Diterpenoids Euphorbiaceae Plants	VEGFR Apoptosis
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the *Akt-STAT3-mTOR* signaling pathway and reduces the expression of VEGF in A549 cells .

HY-N4176

Ginkgolide K	Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Ginkgo biloba	Autophagy
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-N10093

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-N0047

Polyphyllin I 1 Publications Verification	Structural Classification Liliaceae Classification of Application Fields Paris polyphylla Smith Plants Disease Research Fields Saccharides Steroids Cancer	JNK mTOR Akt PDK-1 Autophagy Apoptosis
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of *PDK1/Akt/mTOR* signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .

HY-N0109

Salidroside Maximum Cited Publications 21 Publications Verification Rhodioloside	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Source classification Phenols Plants Disease Research Fields Cancer	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating *mTOR* signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-N6843

Arnicolide D 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Disease Research Fields Cancer	Caspase PI3K Akt mTOR STAT
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the *PI3K/AKT/mTOR* and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .

HY-N2602

Sanggenol L	Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of *PI3K/Akt/mTOR* signaling and cell cycle arrest via activation of p53 in p

HY-N1338

Royleanone NSC 122417	Quinones Structural Classification Anthraquinones Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	mTOR Akt
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits *mTOR/PI3/AKT* signaling pathway in LNCaP prostate cancer cells .

HY-N0279

Cardamonin 5+ Cited Publications Cardamomin; Alpinetin chalcone	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Boesenbergia rotunda Plants Disease Research Fields Cancer Zingiberaceae	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit *mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-N2590

Lupenone	Triterpenes Structural Classification Classification of Application Fields Source classification Musaceae Plants Compositae Infection Terpenoids Astragalus oleifolius DC. Musa basjoo Sieb. et Zucc. Inflammation/Immunology Disease Research Fields Cancer	Parasite PI3K Akt mTOR NF-κB
Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the *PI3K/Akt/mTOR* and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities .

HY-N6950

Hederacolchiside A1 1 Publications Verification	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	PI3K Akt mTOR Parasite Apoptosis
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating *PI3K/Akt/mTOR* signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

HY-N5136

25(R,S)-Ruscogenin	Liliaceae Microorganisms Classification of Application Fields Source classification Liriope platyphylla Wang et Tang Plants Disease Research Fields Steroids Cancer	Apoptosis PI3K Akt mTOR
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the *PI3K/Akt/mTOR* signaling pathway . And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

HY-N0109R

Salidroside (Standard) Rhodioloside (Standard)	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Source classification Phenols Plants Disease Research Fields Cancer	Prolyl Endopeptidase (PREP) mTOR Apoptosis PINK1/Parkin
Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating *mTOR* signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy .

HY-125927

8-Aminoadenosine 8-NH2-Ado	Structural Classification Natural Products Source classification Endogenous metabolite	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks *Akt/mTOR* signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

HY-N2447

Amarogentin 2 Publications Verification	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits *mTOR* signaling .

HY-N0787

Cryptochlorogenic acid 1 Publications Verification 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid	Structural Classification Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields Morus alba Linn.	Endogenous Metabolite NF-κB Keap1-Nrf2 mTOR HIF/HIF Prolyl-Hydroxylase
Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ *mTOR* / HIF-1α signaling pathway Induced physiological stress response .

HY-100542

D-α-Hydroxyglutaric acid disodium 3 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits *mTOR* signaling .

HY-N8380

(-)-Latifolin	Structural Classification Dalbergia hupeana Hance Source classification Phenols Polyphenols Plants Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting *PI3K/AKT/mTOR/p70S6K* signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

Cat. No.	Product Name	Chemical Structure

HY-N0486S

L-Leucine-d10

L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S9

L-Leucine-d3

L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S13

L-Leucine-15N,d10

L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S11

L-Leucine-d1

L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S4

L-Leucine-d7

L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S12

L-Leucine-d2

L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S2

L-Leucine-13C6

Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S1

L-Leucine-13C

L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S3

L-Leucine-15N

L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].
HY-N0486S10

L-Leucine-18O2

L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S5

L-Leucine-2-13C

L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
HY-N0486S8

L-Leucine-13C6,15N

L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S6

L-Leucine-2-13C,15N
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-N0486S7

L-Leucine-1-13C,15N
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

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