Network Version
5-Azacytidine Data Sheet
| Product Name: | 5-Azacytidine |
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|---|---|---|
| CAS No.: | 320-67-2 | |
| Cat. No.: | HY-10586 | |
| MWt: | 244.2 | |
| Formula: | C8H12N4O5 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 31 mg/mL (126.95 mM); H2O : 33.33 mg/mL (136.49 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer Infection | |
| Biological Activity: | ||
| 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4]. IC50 & Target:IC50: DNA methyltransferases; autophagy[1] In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine[1]. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity[2]. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively[3]. In Vivo: TdR-3H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer[3]. | ||
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