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5-Azacytidine

(Synonyms: Azacitidine; 5-AzaC; Ladakamycin)
139 Cited Publications
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Based on 139 publication(s) in Google Scholar

5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.

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  • Purity: 98.03%
  • CAS No.: 320-67-2
  • Formula: C8H12N4O5
  • Molecular Weight:244.20
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • 5-Azacytidine Chemical Structure
    5-Azacytidine Chemical Structure
  • Experimental Validation Results for 5-Azacytidine
  • Experimental Validation Results for 5-Azacytidine
  • Experimental Validation Results for 5-Azacytidine
  • Experimental Validation Results for 5-Azacytidine
  • Experimental Validation Results for 5-Azacytidine
CAS No.: 320-67-2
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  • 5-Azacytidine Chemical Structure
    5-Azacytidine Chemical Structure
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    5-Azacytidine purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jan;637(8045):461-469. [Abstract]

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     5-Azacytidine (5 μM, 5 days) reverses FBP1 promoter methylation and restores FBP1 protein levels in SK-HEP-1 and HepG2 cells.

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    5-Azacytidine purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Jul 22:76:101120. [Abstract]

    Customer Validation
     Western blot were conducted to examine the BCL7A levels in AML cells treated with different concentrations of 5-AzaC (5-Azacytidine) (0, 20, 40 μM).

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    5-Azacytidine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 4;22(1):195. [Abstract]

    Customer Validation
     5-Azacytidine (5µM; 72 h) increases the expression of LIG1 in GEM-resistant cells.

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    5-Azacytidine purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2022 Dec 31;223(Pt A):916-930. [Abstract]

    Customer Validation
     5-azacytidine (5-AzaC; 5 μM; 1, 2, 3 days) results in an increase in the expression of MYOD1 and MYOG during myoblast differentiation.

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    5-Azacytidine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

    Customer Validation
     The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

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