TGF-beta Receptor
Transforming growth factor-beta receptors (TGF-βR) are the serine/threonine kinase receptors that mediate signaling of the TGF-β family. The system is built on two cooperating kinases: TGFBR2 (type II receptor), which constitutively active, first binds TGF-β1/2/3 and then recruits and phosphorylates TGFBR1 (ALK5, type I receptor); TGFBR1 then phosphorylates receptor-regulated SMAD2 and SMAD3, which complex with SMAD4 and translocate to the nucleus to govern genes controlling proliferation arrest, extracellular matrix production, epithelial-mesenchymal transition and immune suppression. TGF-β receptors also activate non-canonical routes including p38, JNK, ERK, Rho GTPases and PI3K-AKT. TGFBR1/2 are ubiquitously expressed; their loss releases tumor cells from TGF-β growth inhibition, while excessive signaling drives fibrosis and cancer metastasis. Germline TGFBR1/TGFBR2 mutations cause Marfan syndrome type 2 and Loeys-Dietz syndrome with arterial aneurysms, and small-molecule TGFBR1 inhibitors (galunisertib) are under evaluation in cancer and fibrosis.
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TGF-beta Receptor Recombinant Proteins (22)
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Inhibitors & Agonists (353)
TGFBR1/ALK-5 Protein, Human (Active, sf9, His-GST)
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Cat. No.: HY-P74522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
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TGFBR2/TGF-beta RII Protein, Human (HEK293, mFc-Avi)
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Cat. No.: HY-P78524
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kinase; TBR-Ii; TGF-Beta Receptor Type IIB; TGFR-2; TGF-Beta Receptor Type II; TBRII; TGFbeta-RII; Transforming Growth Factor, Beta Receptor II (70/80kDa); LDS1B; Transforming Growth Factor-Beta Receptor Type II; LDS2B; Transforming Growth Factor Beta Receptor II; TAAD2; TbetaR-II; AAT3; Transforming Growth Factor, Beta Receptor II Epsilon; FAA3; Transforming Growth Factor, Beta Receptor II Alpha; LDS2; Transforming Growth Factor, Beta Receptor II Delta; RIIC; Transforming Growth Factor Beta Receptor 2; Transforming Growth Factor Beta Receptor Type IIC
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TGFBR2/TGF-beta RII Protein, Human (sf9, His)
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Cat. No.: HY-P73428
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kinase; TBR-Ii; TGF-Beta Receptor Type IIB; TGFR-2; TGF-Beta Receptor Type II; TBRII; TGFbeta-RII; Transforming Growth Factor, Beta Receptor II (70/80kDa); LDS1B; Transforming Growth Factor-Beta Receptor Type II; LDS2B; Transforming Growth Factor Beta Receptor II; TAAD2; TbetaR-II; AAT3; Transforming Growth Factor, Beta Receptor II Epsilon; FAA3; Transforming Growth Factor, Beta Receptor II Alpha; LDS2; Transforming Growth Factor, Beta Receptor II Delta; RIIC; Transforming Growth Factor Beta Receptor 2; Transforming Growth Factor Beta Receptor Type IIC
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TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi)
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Cat. No.: HY-P78525
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
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TGFBR2/TGF-beta RII Protein, Human (Biotinylated, HEK293, Fc-Avi)
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Cat. No.: HY-P78215
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)
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Cat. No.: HY-P73430
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR1/ALK-5 Protein, Human (HEK293, His-Fc)
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Cat. No.: HY-P74523
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
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TGFBR1/ALK-5 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P72453
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Receptor Type-1; TGF-Beta Type I Receptor; ACVRLK4; TGF-Beta Receptor Type I; TBR-I; LDS1A; TBRI; LDS2A; Activin A Receptor Type II-Like Protein Kinase Of 53kD; AAT5; Mutant Transforming Growth Factor Beta Receptor I; LDS1; Activin A Receptor Type II-Like Kinase, 53kDa; Transforming Growth Factor Beta Receptor 1; Transforming Growth Factor Beta Receptor I
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TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc)
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Cat. No.: HY-P77229
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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Lefty-A/TGF-beta 4 Protein, Human (HEK293, His)
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Cat. No.: HY-P70191
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LEFTY2; Left-Right Determination Factor A; Prev. TGFB4; Protein Lefty-2; Prev. EBAF; Protein Lefty-A; LEFTYA; TGF-Beta-4; LEFTA; Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily); Endometrial Bleeding-Associated Factor; Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A); Left-Right Determination Factor 2; Transforming Growth Factor Beta-4; LEFTY2; Left-Right Determination Factor A; Prev. TGFB4; Protein Lefty-2; Prev. EBAF; Protein Lefty-A; LEFTYA; TGF-Beta-4; LEFTA; Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily); Endometrial Bleeding-Associated Factor; Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A); Left-Right Determination Factor 2; Transforming Growth Factor Beta-4
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TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc)
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Cat. No.: HY-P7426
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR3/TGF-beta RIII Protein, Mouse (HEK293, His)
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Cat. No.: HY-P72452
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR3; TGF-Beta Receptor Type III; Transforming Growth Factor Beta Receptor 3; TGF-Beta Receptor Type 3; Betaglycan; Betaglycan Proteoglycan; Transforming Growth Factor Beta Receptor III; TGFR-3; Transforming Growth Factor Beta Receptor Type 3; Transform
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TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His)
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Cat. No.: HY-P7428
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P72454
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
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TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P7427
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR2/TGF-beta RII Protein, Human (Active, sf9, GST)
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Cat. No.: HY-P705574
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kinase; TBR-Ii; TGF-Beta Receptor Type IIB; TGFR-2; TGF-Beta Receptor Type II; TBRII; TGFbeta-RII; Transforming Growth Factor, Beta Receptor II (70/80kDa); LDS1B; Transforming Growth Factor-Beta Receptor Type II; LDS2B; Transforming Growth Factor Beta Receptor II; TAAD2; TbetaR-II; AAT3; Transforming Growth Factor, Beta Receptor II Epsilon; FAA3; Transforming Growth Factor, Beta Receptor II Alpha; LDS2; Transforming Growth Factor, Beta Receptor II Delta; RIIC; Transforming Growth Factor Beta Receptor 2; Transforming Growth Factor Beta Receptor Type IIC
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TGFBR2/TGF-beta RII Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78800
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR2/TGF-beta RII Protein, Mouse (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78801
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR2; Transforming Growth Factor, Beta Receptor II Gamma; Prev. MFS2; Transforming Growth Factor, Beta Receptor II Beta; TGF-Beta Type II Receptor; Serine/Threonine-Protein Kinase Receptor; TGF-Beta Receptor Type-2; Receptor Protein Serine/Threonine Kin
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TGFBR3/TGF-beta RIII Protein, Human (sf9, His)
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Cat. No.: HY-P74521
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR3; TGF-Beta Receptor Type III; Transforming Growth Factor Beta Receptor 3; TGF-Beta Receptor Type 3; Betaglycan; Betaglycan Proteoglycan; Transforming Growth Factor Beta Receptor III; TGFR-3; Transforming Growth Factor Beta Receptor Type 3; Transform
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TGFBR1/ALK-5 Protein, Human (HEK293, Llama Fc)
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Cat. No.: HY-P704918
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Prev. ESS1; Activin Receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
