CD158a/KIR2DL1
CD158a (KIR2DL1) is an inhibitory killer-cell immunoglobulin-like receptor characterized by two extracellular Ig-like domains and a cytoplasmic tail carrying two ITIM motifs. Its ligand specificity is the C2 epitope of HLA-C allotypes, defined by lysine at position 80, and binding is refined by the presented peptide, allowing discrimination between self and altered-self HLA class I. KIR2DL1 is expressed on overlapping subsets of natural killer cells and memory-like T cells as part of the clonally distributed KIR repertoire that shapes NK-cell education and licensing. The presence of KIR2DL1 together with its HLA-C2 ligands influences NK-cell alloreactivity in hematopoietic transplantation and has been linked to pregnancy complications such as pre-eclampsia.
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CD158a/KIR2DL1 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
