1. Stem Cell/Wnt
  2. Gli

Gli

Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription. Research showed that mutating the Gli zinc finger domain inhibited the proteins effect proving its role as a transcription factor. Gli proteins have an 18-amino acid region highly similar to the α-helical herpes simplex viral protein 16 activation domain.

Gli Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-13901
    GANT 61 Inhibitor 99.87%
    GANT 61 is an inhibitor of Gli1 and Gli2, used for cancer research.
  • HY-13282
    GANT 58 Antagonist 99.28%
    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
  • HY-15412
    HhAntag Inhibitor 99.33%
    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.