1. Recombinant Proteins
  2. Fc Receptors
  3. Fc alpha/mu Receptor

The Fc alpha/mu receptor (Fcα/μR, CD351) is a receptor that has dual specificity for IgA and IgM. Fcα/μR binds IgM with high affinity and IgA with a 10-fold lower affinity. Fcα/μR is expressed by both hematopoietic and non-hematopoietic cells, and has been shown to play an important role in humoral immune responses, especially in pro-inflammatory functions of marginal zone B cells in sepsis. Fcα/μR is a type I transmembrane protein that belongs to the immunoglobulin (Ig) superfamily and contains one Ig-like domain in the extracellular portion and a motif in the Ig-like domain conserved in the first Ig-like domain of the human, bovine and rodent poly-IgR. Mouse Fcα/μR contains a dileucine motif at residues 519 and 520 in the cytoplasmic portion that is involved in receptor internalization. However, since the human Fcα/μR does not have a di-leucine motif in its cytoplasmic domain, it remains unclear whether and how it transduces a signal in humans.

Cat. No. Product Name / Synonyms Species Source
  • HY-P77363
    FCAMR/CD351 Protein, Mouse (HEK293, His)

    High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Fc alpha/mu receptor; uR

    Mouse HEK293
    FCAMR/CD351, functioning as a receptor, exhibits high-affinity binding to the Fc fragment of IgA and IgM. It plays a role in the immune response by mediating the endocytosis of IgA and IgM during the immune response to microbes. FCAMR/CD351 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FCAMR/CD351 protein, expressed by HEK293 , with C-His labeled tag. The total length of FCAMR/CD351 Protein, Mouse (HEK293, His) is 420 a.a., with molecular weight of ~46.4 KDa.
Cat. No. Product Name Effect Purity