1. GPCR/G Protein
  2. Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Related Products (46):

Cat. No. Product Name Effect Purity
  • HY-U00418
    ARS-1620 Inhibitor 98.02%
    ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
  • HY-19706
    ARS-853 Inhibitor 98.39%
    ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 μM.
  • HY-15723A
    NSC 23766 trihydrochloride Inhibitor 99.10%
    NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
  • HY-101295
    Pan-RAS-IN-1 Inhibitor >98.0%
    Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
  • HY-12755
    ML141 Inhibitor 99.21%
    ML141(CID-2950007) is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase(IC50=200 nM) with low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7).
  • HY-114277
    AMG-510 Inhibitor
    AMG-510 is a potent KRAS G12C covalent inhibitor.
  • HY-114436
    MRTX-1257 Inhibitor
    MRTX-1257 is a selective, irreversible, covalent and oral active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.
  • HY-114277A
    AMG-510 racemate Inhibitor
    AMG-510 racemate is the racemate of AMG-510. AMG-510 is a potent KRAS G12C covalent inhibitor.
  • HY-14754
    Salirasib Inhibitor 98.72%
    Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.
  • HY-12646
    Rhosin hydrochloride Inhibitor 99.24%
    Rhosin Hcl is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
  • HY-16659
    EHT 1864 Inhibitor 99.60%
    EHT 1864 is a small molecule inhibitor of Rac1 signaling; modulate γ-Secretase-mediated APP processing.
  • HY-12874
    CASIN Inhibitor 98.64%
    CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.
  • HY-104064
    1A-116 Inhibitor 99.28%
    1A-116 is a specific Rac1 inhibitor.
  • HY-12810
    EHop-016 Inhibitor 99.36%
    EHop-016 is a novel potent and selective inhibitor of Rac GTPase; inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 uM.
  • HY-13991
    CCG-1423 Inhibitor 99.92%
    CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis.
  • HY-100876
    GGTI298 Inhibitor
    GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
  • HY-13963
    ZCL278 Inhibitor
    ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
  • HY-U00417
    ARS-1630 Inhibitor 98.01%
    ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
  • HY-18707
    K-Ras(G12C) inhibitor 12 Inhibitor >98.0%
    K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.
  • HY-12649
    Y16 Inhibitor
    Y16 is an inhibitor of G-protein–coupled Rho GEFs; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
Isoform Specific Products

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