Isotope-Labeled Recombinant Proteins

[U-¹⁵N]-CRP is the ¹⁵N-labeled CRP. C-reactive protein (CRP) is a crucial biomarker reflecting inflammatory status and is associated with conditions such as infections, cardiovascular diseases, and autoimmune disorders. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-TSH is the ¹⁵N-labeled TSH. Thyroid-stimulating hormone (TSH) dysfunction is closely associated with primary and secondary thyroid disorders and serves as a key biomarker for the diagnosis and classification of thyroid diseases. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-Aβ(1-40)/[U-¹⁵N]-Aβ(1-42) is the ¹⁵N-labeled Aβ(1-40) and Aβ(1-42). Abnormal levels and aggregation of beta-amyloid (Aβ) in the brain are considered key factors in the pathogenesis of Alzheimer's disease (AD). This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-AFP is the ¹⁵N-labeled AFP. Abnormally elevated levels of alpha-fetoprotein (AFP) serve as a key indicator for the diagnosis and monitoring of primary liver cancer and tumors such as testicular and ovarian cancers. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-α-Synuclein is the ¹⁵N-labeled α-Synuclein. Abnormal levels and aggregation of α-synuclein in the brain are considered key factors in the pathogenesis of Parkinson's disease. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-CYFRA21-1 is the ¹⁵N-labeled CYFRA21-1. Cytokeratin 21-1 (CYFRA21-1) is a common biomarker for tumors of epithelial origin. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-NfL is the ¹⁵N-labeled NfL. Neurofilament light chain (NfL) is a major component of neuronal axonal intermediate filaments and serves as a specific marker of neuronal injury in conditions such as neurodegenerative diseases and traumatic brain injury. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-GFAP is the ¹⁵N-labeled GFAP. Abnormal expression of glial fibrillary acidic protein (GFAP) can serve as a key biomarker for conditions such as brain injury and neurodegenerative diseases. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-PIVKA-II is the ¹⁵N-labeled PIVKA-II. Abnormally elevated levels of PIVKA-II (protein induced by vitamin K absence or antagonist-II) are closely associated with hepatocellular carcinoma; it is a significant biomarker for liver cancer, offering particular diagnostic value for AFP-negative cases. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-PD-L1 is the ¹⁵N-labeled PD-L1. PD-L1 is expressed on immune cells or aberrantly overexpressed on the surface of various tumor cells; it maintains immune tolerance and acts as a key molecule in tumor immune escape. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-OPN is the ¹⁵N-labeled OPN.

[U-¹⁵N]-rhFGF23 is the ¹⁵N-labeled rhFGF23. Abnormal levels of recombinant human fibroblast growth factor 23 (rhFGF23) are closely associated with chronic kidney disease and metabolic disorders such as hypophosphatemia and hyperphosphatemia. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-γ-Synuclein is the ¹⁵N-labeled γ-Synuclein.

[U-¹³C,¹⁵N]-IGF-2 is the ¹³C- and ¹⁵N-labeled IGF-2. Abnormal levels of insulin-like growth factor 2 (IGF-2) are closely associated with conditions such as fetal growth restriction, tumors, and metabolic disorders. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-TG-domain4 is the ¹⁵N-labeled TG-domain4. TG-domain 4, a key functional region of thyroglobulin (TG), is a significant biomarker associated with monitoring thyroid cancer recurrence, autoimmune thyroid diseases, and thyroid dysfunction. This isotope-labeled form can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-TG-domain2 is the ¹⁵N-labeled TG-domain2. Thyroglobulin (TG-domain 2) is involved in iodine binding and hormone modification, serving as an important biomarker for thyroid cancer, autoimmune thyroiditis, and thyroid dysfunction. This isotope-labeled form can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-Renin24-406 is the ¹⁵N-labeled Renin24-406.

[U-¹³C,¹⁵N]-IGF-1 is the ¹³C- and ¹⁵N-labeled IGF-1. Abnormal expression of insulin-like growth factor 1 (IGF-1) is associated with various conditions, including growth hormone deficiency, diabetes, and the development of certain tumors. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis.

[U-¹⁵N]-Proinsulin is the ¹⁵N-labeled Proinsulin.