2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Serine/Threonine Kinase Proteins
  5. NEK7

NEK7

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Cat. No. Product Name / Synonyms Species Source
  • HY-P701253
    NEK7 Protein, Human (His-SUMO)

    Serine/threonine-protein kinase Nek7; NimA-related protein kinase 7; NEK7

    		Human E. coli
    NEK7 Protein, a pivotal kinase, crucially drives mitotic cell cycle progression by enhancing centrosome microtubule nucleation, ensuring robust spindle formation, and aiding cytokinesis. Its phosphorylation of EML4 at 'Ser-146' facilitates chromosome congression. NEK7 extends its impact by phosphorylating RPS6KB1 and activating NLRP3 inflammasome assembly, promoting CASP1 activation. Independently, NEK7 unlocks NLRP3 within the microtubule organizing center, ensuring mutual exclusivity between inflammasome response and cell division by interacting with NEK9. These multifaceted functions position NEK7 as a key orchestrator in mitotic progression and the inflammasome response, highlighting its regulatory significance. NEK7 Protein, Human (His-SUMO) is the recombinant human-derived NEK7 protein, expressed by E. coli. The total length of NEK7 Protein, Human (His-SUMO) is 302 a.a., with molecular weight of 50 kDa.
  • HY-P75935
    NEK7 Protein, Human (sf9, His-GST)

    Serine/threonine-protein kinase Nek7; NimA-related protein kinase 7; NEK7

    		Human Sf9 insect cells
    The NEK7 protein is a key kinase that crucially drives mitotic cell cycle progression by enhancing centrosomal microtubule nucleation, ensuring robust spindle formation, and aiding in cytokinesis. Phosphorylation of EML4 at “Ser-146” promotes chromosome aggregation. NEK7 Protein, Human (sf9, His-GST) is the recombinant human-derived NEK7 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of NEK7 Protein, Human (sf9, His-GST) is 302 a.a., with molecular weight of ~58 kDa.
Cat. No. Product Name Effect Purity