1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins
  3. Ephrin/Eph Family Enzyme-linked receptors
  4. Eph receptors

Eph proteins belong to the superfamily of transmembrane receptor tyrosine kinases. Eph receptors have been conserved in a variety of eukaryotic species from Caenorhabditis elegans to human. Eph receptors can be classified into EphA or EphB subfamilies, 9 EphA and 5 EphB rodent members, depending on whether they preferentially bind to membrane-anchored glycosyl phosphatidylinositol (GPI)-linked or transmembrane Ephrin ligands, referred to as Ephrin-As and Ephrin-Bs, respectively. Exceptionally, EphA4 binds to Ephrin-B ligands 3, and EphB2 binds to ephrin-A5. The Ephrin/Eph signaling pathway is involve their interaction with specific intracellular proteins, including non-catalytic region of Tyr kinase adaptor protein 1 (Nck1) and Nck2, phosphoinositide 3-kinase (PI3K), Src family kinases, Vav2, Vav3 and ephexin. In turn, these effectors are coupled to Rho GTPases such as Rac1 and RhoA, which can modulate the cytoskeleton. The Eph/ephrin signaling plays important roles in developmental processes, adult tissue homeostasis and various diseases. Its abnormal function has been implicated in various diseases, including cancer. (Targeting Ephrin Receptor )

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