1. NF-κB
  2. IKK

IKK

IKK (IκB kinase) is an enzyme complex that is involved in propagating the cellular response to inflammation. An IκB kinase is an enzyme that catalyzes the chemical reaction: ATP + IκB protein ADP + IκB phosphoprotein. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. IKK specifically, phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is free migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic. IKK belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins.

IKK Isoform Specific Products:

  • IKK-α

  • IKK-β

  • IKK

  • IKKε

  • TBK1

IKK Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-16561
    Resveratrol Inhibitor 98.90%
    Resveratrol, a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has a wide spectrum of targets including mTOR, JAK, β-amyloid.
  • HY-13018
    MRT67307 Inhibitor 99.00%
    MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively.
  • HY-10518
    BMS-345541 Inhibitor 99.77%
    BMS-345541 is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
  • HY-B0713
    Amlexanox Inhibitor 99.32%
    AmLexanox is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
  • HY-15473
    MLN120B Inhibitor 99.03%
    MLN120B is a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM.
  • HY-18710
    BMS-066 Inhibitor
    BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively.
  • HY-19383
    Ertiprotafib Inhibitor
    Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
  • HY-10074
    TPCA-1 Inhibitor 99.54%
    TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM.
  • HY-13060
    ACHP Hydrochloride Inhibitor 98.03%
    ACHP Hydrochloride is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.
  • HY-13687
    IKK 16 Inhibitor 99.78%
    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
  • HY-10172
    IMD-0354 Inhibitor 99.46%
    IMD-0354 is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC 50 of 1.2±0.3 uM.
  • HY-B0788
    LY2409881 Inhibitor 98.89%
    LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
  • HY-13802
    SC-514 Inhibitor 99.99%
    SC-514 is a selective IKK-2 inhibitor (IC50=11.2±4.7 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
  • HY-13019
    BI605906 Inhibitor 99.68%
    BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
  • HY-10519
    BMS-345541 free base Inhibitor 99.17%
    BMS-345541 free base is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
  • HY-50948
    Bay 65-1942 hydrochloride Inhibitor 99.05%
    Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.
  • HY-12453
    TBK1/IKKε-IN-2 Inhibitor 98.50%
    TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
  • HY-18008
    PS-1145 Inhibitor 99.93%
    PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
  • HY-19362
    AZD3264 Inhibitor 98.77%
    AZD3264 is a selective IkB-kinase IKK2 inhibitor.
  • HY-13873
    IKK-IN-1 Inhibitor
    IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.