1. NF-κB
  2. IKK

IKK

IKK (IκB kinase) is an enzyme complex that is involved in propagating the cellular response to inflammation. An IκB kinase is an enzyme that catalyzes the chemical reaction: ATP + IκB protein ADP + IκB phosphoprotein. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. IKK specifically, phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is free migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic. IKK belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins.

IKK Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-16561
    Resveratrol Inhibitor 98.90%
    Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
  • HY-13018
    MRT67307 Inhibitor 99.02%
    MRT67307 is a dual inhibitor of the IKKε and TBK-1, which mediates the phosphorylation of interferon regulatory factor 3 (IRF3), with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, and also targets ULK1 and ULK2 with high potency (IC50 values of 45 and 38 nM, respectively).
  • HY-15473
    MLN120B Inhibitor 99.03%
    MLN120B is a novel IKKβ inhibitor, used for cancer treatment.
  • HY-10074
    TPCA-1 Inhibitor 99.54%
    TPCA-1 is a potent inhibitor of IKK-2 with IC50 of 17.9 nM.
  • HY-10518
    BMS-345541 Inhibitor 99.77%
    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
  • HY-13873
    IKK-IN-1 Inhibitor
    IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
  • HY-105661
    IMD-0560 Inhibitor 98.68%
    IMD-0560 is a novel IκB kinase β inhibitor.
  • HY-B0713
    Amlexanox Inhibitor 99.32%
    AmLexanox is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
  • HY-N1201
    Apigenin Inhibitor >98.0%
    Apigenin is a non-toxic and non-mutagenic flavone that exists abundantly in numerous herbs and vegetables.
  • HY-13019
    BI605906 Inhibitor 99.68%
    BI605906, a novel inhibitor of IKKβ, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
  • HY-13687
    IKK 16 Inhibitor 99.78%
    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
  • HY-B0788
    LY2409881 Inhibitor 98.77%
    LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.
  • HY-13060
    ACHP Hydrochloride Inhibitor 98.03%
    ACHP Hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
  • HY-N0014
    Icariin Inhibitor >98.0%
    Icariin(Ieariline) is a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum; exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities.
  • HY-10519
    BMS-345541 free base Inhibitor 99.69%
    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
  • HY-10172
    IMD-0354 Inhibitor 99.94%
    IMD-0354 is a synthetic selective NF-kB inhibitor.
  • HY-13802
    SC-514 Inhibitor 99.99%
    SC-514 (GK 01140), a small molecule, is a selective inhibitor of IKK-2; does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
  • HY-19362
    AZD3264 Inhibitor 99.70%
    AZD 3264 is an IkB-kinase IKK2 Inhibitor, IKK2 has been identified as one of the novel pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
  • HY-18008
    PS-1145 Inhibitor 99.93%
    PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.
  • HY-12453
    IKK epsilon-IN-1 Inhibitor 98.50%
    IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.