1. Signaling Pathways
  2. PROTAC
  3. AUTAC

AUTAC

Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.

AUTAC Related Products (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134640
    AUTAC4 2267315-04-6 99.12%
    AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy.
    AUTAC4
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