1. Autophagy
  2. Mitophagy
  3. AUTAC4

AUTAC4 

Cat. No.: HY-134640
Handling Instructions

AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy.

For research use only. We do not sell to patients.

AUTAC4 Chemical Structure

AUTAC4 Chemical Structure

CAS No. : 2267315-04-6

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5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy[1].

In Vitro

AUTAC4 induces K63-linked polyubiquitination. Accumulation of K63-linked polyubiquitin required approximately 8 h of incubation[1].
AUTAC4 suppresses not only cytochrome c release into the cytosol but also pro-caspase 3 cleavage. The intracellular ATP level after CCCP treatment is also maintained by AUTAC4, suggesting that mitophagy acceleration by AUTAC4 restored energy production by improving mitochondrial quality control. AUTAC4 rescues cells with acute mitochondrial injury by promoting mitophagy[1].
With the use of mito-Rosella, AUTAC4 (10 μM) can induce mitophagy in Detroit 532 cells ~24-72 h after treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

869.96

Formula

C₄₃H₄₈FN₉O₈S

CAS No.
SMILES

O=C(NCCCOCCOCCOCCCNC([[email protected]](CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NC(C)=O)=O)C(C4=C(C5=CC=CC=C5)NC6=C4C=CC=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (229.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1495 mL 5.7474 mL 11.4948 mL
5 mM 0.2299 mL 1.1495 mL 2.2990 mL
10 mM 0.1149 mL 0.5747 mL 1.1495 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (5.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (5.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AUTAC4AUTAC 4AUTAC-4MitophagyMitochondrial AutophagyAUTACmitochondriacytosolicautophagyInhibitorinhibitorinhibit

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AUTAC4
Cat. No.:
HY-134640
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