Hepatitis C virus E2 Proteins
The E2 glycoprotein of hepatitis C virus is the major surface antigen and the principal determinant of receptor engagement. Its globular core binds CD81 and, together with E1, cooperates with scavenger receptor SR-BI, claudin-1 and occludin to trigger entry, followed by pH-dependent fusion. E2 contains two hypervariable regions, HVR1 and HVR2, and extensive glycan shielding that drive immune escape and viral quasispecies diversity, which is why natural infection rarely confers sterilizing immunity. Neutralizing antibodies targeting E2 epitopes are broadly reactive in some cases, making E2 the leading antigen for HCV vaccine design. Recombinant E2 is used in neutralization assays, receptor-binding studies and immunogen discovery.
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Hepatitis C virus E2 Recombinant Proteins (3)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
