1. Isotope-Labeled Compounds
  2. Deuterium (2H, D)

Deuterium (2H, D)

Deuterium (Hydrogen-2, or D) is one of the stable isotope atom of hydrogen,it contains one proton and one neutron, also known as heavy hydrogen. At present, the research on the introduction of deuterium into new drugs and the intermediate molecules is increasing. These deuterium-containing compounds can also be used as tracers and internal standards, etc.

Deuterium (2H, D) (4913):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15162A
    MMAE-d8 2070009-72-0 99.29%
    MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
  • HY-19939S
    VX-984 1476074-39-1 99.20%
    VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium.
  • HY-13631AS
    Exatecan-d5 (mesylate) 2819276-88-3 99.77%
    Exatecan-d5 (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].
    Exatecan-d<sub>5</sub> (mesylate)
  • HY-B0863
    Glyphosate 1071-83-6 ≥98.0%
    Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants.
  • HY-131968
    BMS-986202 1771691-34-9 99.92%
    BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium.
  • HY-Y0338S2
    Ethylene glycol-d4 2219-51-4 98.5%
    Ethylene glycol-d4 is the deuterium labeled Ethylene glycol[1].
    Ethylene glycol-d<sub>4</sub>
  • HY-111772S1
    Elexacaftor-d3 99.23%
    Elexacaftor-d3 (VX-445-d3) is the deuterium labeled Elexacaftor (HY-111772).
  • HY-Y0688S
    1H-Benzotriazole-4,5,6,7-d4 1185072-03-0
    1H-Benzotriazole-4,5,6,7-d4 is the deuterium labeled 1H-Benzo[d][1,2,3]triazole[1].
  • HY-13631DS
    Dxd-d5 98.63%
    Dxd-d5 is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1].
  • HY-B1260
    Cetrimonium bromide 57-09-0 ≥98.0%
    Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.
    Cetrimonium bromide
  • HY-15331
    VD3-d6 118584-54-6 ≥98.0%
    VD3-d6 is the deuterium labeled Vitamin D3; tools for determination of Vitamin D3 metabolites in human serum.
  • HY-128463
    N-tert-Butyl-α-phenylnitrone 3376-24-7 99.87%
    N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier.
  • HY-15328
    25-Hydroxy VD2-d6 1262843-46-8 98.96%
    25-Hydroxy VD2-d6 is the deuterium labeled 25-Hydroxy VD2.
    25-Hydroxy VD2-d<sub>6</sub>
  • HY-15777AS
    Ribociclib-d6 (hydrochloride) 99.24%
    Ribociclib-d6 (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
    Ribociclib-d<sub>6</sub> (hydrochloride)
  • HY-18569S
    3-Indoleacetic acid-d5 76937-78-5 99.84%
    3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].
    3-Indoleacetic acid-d<sub>5</sub>
  • HY-78131S
    Ibuprofen-d3 121662-14-4 99.18%
    Ibuprofen-d3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].
  • HY-17587
    4-Methylbenzylidene camphor 36861-47-9 99.86%
    4-Methylbenzylidene camphor(4-MBC; Enzacamene)is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
    4-Methylbenzylidene camphor
  • HY-10219S
    Rapamycin-d3 392711-19-2
    Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
  • HY-113147AS
    L-Palmitoylcarnitine-d3 (hydrochloride) 1334532-26-1 99.83%
    L-Palmitoylcarnitine-d3 (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
    L-Palmitoylcarnitine-d<sub>3</sub> (hydrochloride)
  • HY-15463S1
    Imatinib-d4 1134803-16-9 99.97%
    Imatinib-d4 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].