1. Isotope-Labeled Compounds
  2. Deuterium (2H, D)

Deuterium (2H, D)

Deuterium (Hydrogen-2, or D) is one of the stable isotope atom of hydrogen,it contains one proton and one neutron, also known as heavy hydrogen. At present, the research on the introduction of deuterium into new drugs and the intermediate molecules is increasing. These deuterium-containing compounds can also be used as tracers and internal standards, etc.

Deuterium (2H, D) (5250):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15162A
    MMAE-d8 2070009-72-0 99.29%
    D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
  • HY-19939S
    VX-984 1476074-39-1 99.20%
    VX-984 is a potent DNA-PK inhibitor.
  • HY-13631AS
    Exatecan-d5 mesylate 99.77%
    Exatecan D5 mesylate (DX8951f-D5) is deuterium labeled Exatecan Mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL.
    Exatecan-d5 mesylate
  • HY-131968
    BMS-986202 1771691-34-9 99.46%
    BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research.
  • HY-15579AS
    MMAF-d8 hydrochloride 98.97%
    D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
    MMAF-d8 hydrochloride
  • HY-I1124
    L-Valine-d8 35045-72-8 ≥99.0%
    L-Valine-d8 (L-VALINE-2,3,4,4,4,5,5,5-d8) is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.
  • HY-N0437S
    Progesterone-d9 15775-74-3
    Progesterone-d9 (Pregn-4-ene-3,20-dione-d9) is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-N0650S8
    L-Serine-d3 105591-10-4
    L-Serine-d3 ((-)-Serine-d3) is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
  • HY-10201S
    Sorafenib-d3 1130115-44-4 99.08%
    Sorafenib-d3 (Bay 43-9006-d3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
  • HY-13631DS
    Dxd-D5 (Exatecan-D5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .
  • HY-32349S
    Ercalcidiol-d3 1217467-39-4 99.08%
    Ercalcidiol-d3 (25-hydroxy Vitamin D2-d3) is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status.
  • HY-104077S
    Remdesivir-d5 99.58%
    Remdesivir-D5 (GS-5734-D5) is a deuterium labeled Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro.
  • HY-B0421S
    Mycophenolic acid-d3 1185242-90-3 98.96%
    Mycophenolic acid D3 (Mycophenolate D3) is deuterium labeled Mycophenolic acid, which is an an immunosuppresant drug and has potent anti-proliferative activity.
    Mycophenolic acid-d3
  • HY-B0113S
    Omeprazole-d3 922731-01-9 98.99%
    Omeprazole D3 (H 16868 D3) is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
  • HY-76814
    Calcitriol-d6 78782-99-7 99.12%
    Calcitriol D6 is the deuterated form of Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ), which is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
  • HY-W050026S
    Phenylacetylglutamine-d5 1331909-01-3 98.01%
    Phenylacetylglutamine-D5 (NSC 203800-D5;Phenylacetyl-L-glutamine-D5) is a deuterated form of Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
  • HY-B0801S
    Fexofenadine-d6 548783-71-7 99.28%
    Fexofenadine D6 (MDL-16455 D6) is deuterium labeled is Fexofenadine, which is an antihistamine pharmaceutical agent.
  • HY-15772S
    Osimertinib-d6 1638281-44-3 99.70%
    Osimertinib D6 (AZD-9291 D6) is a deuterium labeled osimertinib. Osimertinib is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.
  • HY-15777AS
    Ribociclib-d6 hydrochloride 98.37%
    Ribociclib D6 (LEE011 D6) hydrochloride is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
    Ribociclib-d6 hydrochloride
  • HY-A0020S
    Eldecalcitol-d6 99.26%
    Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.