1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Isomerases (EC 5)

Enzymes can be classified systematically according to the difference between reaction and substrate specificity, and the mechanism of action. Isomerases (EC 5.x.x.x) are a group of enzymes that catalyze isomerization reactions include the epimerases, racemases, and intramolecular transferases. This process involves the change in bond connectivity or spatial arrangements within a single substrate molecule, generating a product with the same chemical formula (described as an isomer). Isomerases are present in the metabolism and genome of most living organisms, catalysing up to 4% of the biochemical reactions present in central metabolism, in particular, carbohydrate metabolism. There are six isomerase EC subclasses: 1) Racemases, epimerases; 2) Cis-trans isomerases; 3) intramolecular oxidoreductases; 4) intramolecular transferases; 5) intramolecular lyases; 6) Other isomerases. Most of the isomerase reactions are unimolecular (one substrate and one product).

Cat. No. Product Name / Synonyms Species Source
  • HY-P70823
    TSLPR Protein, Mouse (HEK293, Fc)

    CRL2; CRLF2; CRL2 cytokine receptor; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR

    Mouse HEK293
    Cytokine receptor-like factor 2 (Crlf2), also known as thymic stromal lymphopoietin (TSLP) receptor, is a receptor for TSLP. Crlf2 can forms a functional complex with TSLP and IL7RA, and overexpression of Crlf2 stimulates cell proliferation through activation of the JAK-STAT pathway. The expression of Crlf2 usually upregulates and mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL). TSLPR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TSLPR protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P76289
    CRELD2 Protein, Mouse (HEK293, His)

    Cysteine-Rich With EGF-Like Domain Protein 2; CRELD2

    Mouse HEK293
    CRELD2 Protein, potentially acting as a protein disulfide isomerase, may play a role in the unfolded protein response. It is also implicated in regulating the transport of the alpha4-beta2 neuronal acetylcholine receptor, showcasing its versatility in cellular processes related to protein folding and neuronal receptor dynamics. These functions suggest CRELD2's involvement in maintaining cellular homeostasis. CRELD2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CRELD2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P70011
    Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution)

    rHuPeptidyl-prolyl cis-trans isomerase B/PPIB, His; CYP-S1; CYPB; HEL-S-39; OI9; SCYLP

    Human HEK293
    Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is 179 a.a., with molecular weight of ~21.0 kDa.
  • HY-P70047
    Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human

    rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA

    Human E. coli
    CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.
  • HY-P71242
    PTGDS Protein, Human (HEK293, His)

    Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS

    Human HEK293
    The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PTGDS Protein, Human (HEK293, His) is 168 a.a., with molecular weight of 20-29 kDa.
  • HY-P71113
    PDIA4 Protein, Human (HEK293, His)

    Protein Disulfide-Isomerase A4; Endoplasmic Reticulum Resident Protein 70; ER Protein 70; ERp70; Endoplasmic Reticulum Resident Protein 72; ER Protein 72; ERp-72; ERp72; PDIA4; ERP70; ERP72

    Human HEK293
    The PDIA4 protein plays a key role in the chaperone complex, cooperating with various proteins. This dynamic assembly, including DNAJB11, HSP90B1 and others, orchestrates complex cellular processes. PDIA4 Protein, Human (HEK293, His) is the recombinant human-derived PDIA4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA4 Protein, Human (HEK293, His) is 625 a.a., with molecular weight of ~75.0 kDa.
  • HY-P71193
    PDIA6 Protein, Human (HEK293, His)

    Protein Disulfide-Isomerase A6; Endoplasmic Reticulum Protein 5; ER Protein 5; ERp5; Protein Disulfide Isomerase P5; Thioredoxin Domain-Containing Protein 7; PDIA6; ERP5; P5; TXNDC7

    Human HEK293
    PDIA6 protein has molecular chaperone activity, which can inhibit the aggregation of misfolded proteins and contribute to quality control. It negatively regulates the unfolded protein response (UPR) by binding to ERN1 and inhibiting its signaling. PDIA6 Protein, Human (HEK293, His) is the recombinant human-derived PDIA6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA6 Protein, Human (HEK293, His) is 421 a.a., with molecular weight of ~52.0 kDa.
  • HY-P70011A
    Cyclophilin B/PPIB Protein, Human (HEK293, His)

    Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4

    Human HEK293
    Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~19 kDa.
  • HY-P71242A
    PTGDS Protein, Human (HEK293, C-His)

    Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS

    Human HEK293
    The PTGDS protein serves a multifaceted role in various physiological processes. It catalyzes the conversion of PGH2 to PGD2, a prostaglandin with implications in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Beyond its involvement in these vascular functions, PTGDS plays a crucial role in diverse central nervous system (CNS) activities, including sedation, NREM sleep, and PGE2-induced allodynia, and may exhibit an anti-apoptotic function in oligodendrocytes. Notably, PTGDS has a broad substrate-binding capacity, interacting with small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid, and thyroid hormone. This suggests its potential role as a scavenger for harmful hydrophobic molecules and as a transporter for secretory retinoids and thyroid hormones. Additionally, PTGDS is implicated in the development and maintenance of various blood barriers, including the blood-brain, blood-retina, blood-aqueous humor, and blood-testis barriers, indicating its significance in barrier function. Furthermore, it plays essential roles in the maturation and maintenance of the central nervous system and the male reproductive system, as well as participates in PLA2G3-dependent maturation of mast cells, further emphasizing its intricate involvement in diverse biological processes. PTGDS Protein, Human (HEK293, C-His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTGDS Protein, Human (HEK293, C-His) is 168 a.a., with molecular weight of ~21 kDa.
  • HY-P74212
    Cyclophilin A Protein, Mouse (His)

    Peptidyl-prolyl cis-trans isomerase A; PPIase A; SP18; PPIA; CYPA

    Mouse E. coli
    Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag. The total length of Cyclophilin A Protein, Mouse (His) is 164 a.a., with molecular weight of ~18.94 kDa.
  • HY-P70007
    Cyclophilin A Protein, Mouse

    rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA

    Mouse E. coli
    Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free. The total length of Cyclophilin A Protein, Mouse is 164 a.a., with molecular weight of ~17.0 kDa.
  • HY-P74211
    Cyclophilin F/PPIF Protein, Human (HEK293, His, solution)

    Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF

    Human HEK293
    Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is 178 a.a., with molecular weight of ~20.3 kDa.
  • HY-P70059
    ECH1 Protein, Human (His)

    rHuDelta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial/ECH1, His; Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase; mitochondrial; ECH1;

    Human E. coli
    ECH1 Protein plays a crucial role in isomerization, converting 3-trans,5-cis-dienoyl-CoA to its isomeric form, 2-trans,4-trans-dienoyl-CoA. This enzymatic step is vital in metabolic pathways, ensuring the equilibrium of dienoyl-CoA species and contributing to overall metabolic flux. ECH1's activity is essential for maintaining structural rearrangement in Coenzyme A (CoA)-linked intermediates, emphasizing its significance in cellular processes. ECH1 Protein, Human (His) is the recombinant human-derived ECH1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ECH1 Protein, Human (His) is 295 a.a., with molecular weight of 30-35 kDa.
  • HY-P70081
    CRELD2 Protein, Human (HEK293, His)

    rHuProtein disulfide isomerase CRELD2/CRELD2, His; Cysteine-Rich With EGF-Like Domain Protein 2; CRELD2

    Human HEK293
    CRELD2 Protein, potentially acting as a protein disulfide isomerase, may play a role in the unfolded protein response. It is also implicated in regulating the transport of the alpha4-beta2 neuronal acetylcholine receptor, showcasing its versatility in cellular processes related to protein folding and neuronal receptor dynamics. These functions suggest CRELD2's involvement in maintaining cellular homeostasis. CRELD2 Protein, Human (HEK293, His) is the recombinant human-derived CRELD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CRELD2 Protein, Human (HEK293, His) is 297 a.a., with molecular weight of ~41 kDa.
  • HY-P70206A
    Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His)

    rHuMaleylacetoacetate isomerase/GSTZ1, His; Maleylacetoacetate Isomerase; MAAI; GSTZ1-1; Glutathione S-Transferase Zeta 1; GSTZ1

    Human E. coli
    The maleylacetoacetate isomerase/GSTZ1 protein is a member of the GST superfamily and detoxifies electrophilic molecules. It converts maleylacetoacetate to fumarylacetoacetate, a key step in phenylalanine/tyrosine degradation. Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) is the recombinant human-derived Maleylacetoacetate isomerase/GSTZ1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) is 215 a.a., with molecular weight of ~25 kDa.
  • HY-P70418
    UDP-glucose 4-epimerase/GALE Protein, Human (His)

    rHuUDP-glucose 4-epimerase/GALE, His; UDP-Glucose 4-Epimerase; Galactowaldenase; UDP-Galactose 4-Epimerase; GALE

    Human E. coli
    GALE proteins catalyze the reversible epimerization of UDP-glucose to UDP-galactose, and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. UDP-glucose 4-epimerase/GALE Protein, Human (His) is the recombinant human-derived UDP-glucose 4-epimerase/GALE protein, expressed by E. coli , with N-6*His labeled tag. The total length of UDP-glucose 4-epimerase/GALE Protein, Human (His) is 348 a.a., with molecular weight of ~38.23 kDa.
  • HY-P70903
    IDI2 Protein, Human (His)

    Isopentenyl-Diphosphate Delta-Isomerase 2; Isopentenyl Pyrophosphate Isomerase 2; IPP Isomerase 2; IPPI2; IDI2

    Human E. coli
    IDI2 protein plays a crucial role in catalyzing the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP), leading to the formation of its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). This enzymatic activity is a key step in the biosynthetic pathway, contributing to the generation of essential building blocks for various cellular processes. IDI2 Protein, Human (His) is the recombinant human-derived IDI2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDI2 Protein, Human (His) is 227 a.a., with molecular weight of 28-31 kDa.
  • HY-P70903A
    IDI2 Protein, Human (C-His)

    Isopentenyl-Diphosphate Delta-Isomerase 2; Isopentenyl Pyrophosphate Isomerase 2; IPP Isomerase 2; IPPI2; IDI2

    Human E. coli
    IDI2 protein plays a crucial role in catalyzing the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP), leading to the formation of its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). This enzymatic activity is a key step in the biosynthetic pathway, contributing to the generation of essential building blocks for various cellular processes. IDI2 Protein, Human (C-His) is the recombinant human-derived IDI2 protein, expressed by E. coli , with C-8*His labeled tag. The total length of IDI2 Protein, Human (C-His) is 225 a.a., with molecular weight of ~27 kDa.
  • HY-P71036
    HPGDS Protein, Human

    Glutathione-Dependent PGD Synthase; Glutathione-Requiring Prostaglandin D Synthase; Prostaglandin-H2 D-Isomerase; HPGDS; GSTS; PGDS; PTGDS2

    Human E. coli
    HPGDS protein is a multifunctional enzyme with bifunctionality, and its C-terminal and N-terminal domains have different activities. The C terminus acts as an epoxide hydrolase, promoting xenobiotic metabolism by degrading harmful epoxides and regulating physiological mediator levels. HPGDS Protein, Human is the recombinant human-derived HPGDS protein, expressed by E. coli , with tag free. The total length of HPGDS Protein, Human is 199 a.a., with molecular weight of ~26.0 kDa.
  • HY-P71192
    PDIA5 Protein, Human (HEK293, His)

    Protein disulfide-isomerase A5; Protein disulfide isomerase-related protein; PDIA5; PDIR

    Human HEK293
    PDIA5 Protein catalyzes the rearrangement of disulfide bonds in proteins, ensuring proper folding and stabilization. Its vital role maintains protein structure and function, guaranteeing effective performance of designated biological tasks through correct disulfide bond formation. PDIA5 Protein, Human (HEK293, His) is the recombinant human-derived PDIA5 protein, expressed by HEK293, with C-6*His labeled tag. The total length of PDIA5 Protein, Human (HEK293, His) is 241 a.a., with molecular weight of ~30 kDa.
Cat. No. Product Name Effect Purity