Signaling Pathway

Autophagy

Autophagy

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Autophagy Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
Corynoxine

HY-N0901

Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.

Corynoxine B

HY-N0901A

Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.

MHY1485

HY-B0795

MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.

Nimodipine

HY-B0265

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.

SMER18

HY-18672

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.

SMER28

HY-100200

SMER28 is a small molecule modulator of autophagy acting via an mTOR-independent mechanism, prevented the accumulation of amyloid beta peptide.

Spautin-1

HY-12990

Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM.

Tacrolimus monohydrate

HY-13756A

Tacrolimus monohydrate(FK506; FR900506) is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects.