Smo

Smo Related Products (22):

By Effects:	Inhibitors (8) Agonists (4) Antagonists (7) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-17024

Cyclopamine Inhibitor 99.97%

Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
HY-12848

SAG Agonist 99.71%

SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts cyclopamine inhibition of Smo.
HY-15108

Purmorphamine Activator 99.89%

Purmorphamine (Shh Signaling Antagonist VI) is a smoothened receptor agonist with an EC₅₀ of 1 μM.
HY-16582A

Sonidegib Antagonist 99.68%

Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

Cyclopamine	Inhibitor	99.97%
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

SAG	Agonist	99.71%
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts cyclopamine inhibition of Smo.

Purmorphamine	Activator	99.89%
Purmorphamine (Shh Signaling Antagonist VI) is a smoothened receptor agonist with an EC₅₀ of 1 μM.

Sonidegib	Antagonist	99.68%
Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

HY-16391

Glasdegib	Inhibitor	99.31%
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM.

HY-12848C

SAG dihydrochloride	Agonist
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts cyclopamine inhibition of Smo.

HY-131016

IHR-Cy3 Antagonist

IHR-Cy3 is a potent fluorescent Smo antagonist with an IC₅₀ of 100 nM.

IHR-Cy3	Antagonist
IHR-Cy3 is a potent fluorescent Smo antagonist with an IC₅₀ of 100 nM.

HY-12848B

SAG hydrochloride	Agonist	99.98%
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts cyclopamine inhibition of Smo.

HY-12316

20(S)-Hydroxycholesterol	Activator	98.07%
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells.

HY-100224

SANT-1 Antagonist 99.85%

SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.

SANT-1	Antagonist	99.85%
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.

HY-100036

MK-4101	Antagonist	98.31%
MK-4101 is a Smoothened (SMO) antagonist (IC₅₀ of 1.1 µM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC₅₀ of 1.5 µM for mouse cells; IC₅₀ of 1 µM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis.

HY-16582

Sonidegib diphosphate	Antagonist	99.83%
Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

HY-B0877

Halcinonide Agonist 99.08%

Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.

Halcinonide	Agonist	99.08%
Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.

HY-N0836

Jervine	Inhibitor	99.53%
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

HY-16587

Saridegib Inhibitor >99.0%

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
HY-13242

Taladegib Inhibitor 99.93%

Taladegib (LY2940680) is an antagonist of the smoothened receptor.
HY-15412

HhAntag 99.26%

HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway.

Saridegib	Inhibitor	>99.0%
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Taladegib	Inhibitor	99.93%
Taladegib (LY2940680) is an antagonist of the smoothened receptor.

HhAntag		99.26%
HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway.

HY-13809

BMS-833923	Inhibitor
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

HY-18636

LEQ506 Inhibitor 98.27%

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

LEQ506	Inhibitor	98.27%
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

HY-117407

ALLO-2	Antagonist	99.58%
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM.

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