1. Stem Cell/Wnt
  2. Smo


Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation.[3] SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

Smo Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-12848
    SAG Agonist 99.71%
    SAG is a potent Smo receptor agonist which activates the Hedgehog signaling pathway with a Kd of 59 nM.
  • HY-15108
    Purmorphamine Activator 99.89%
    Purmorphamine is a smoothened receptor agonist with an EC50 of 1 μM.
  • HY-16582A
    LDE225 Antagonist 99.68%
    LDE225 is a potent and selective Smoothened (Smo) antagonist with IC50s of 1.3 nM and 2.5 nM for mouse and human Smo, respectively.
  • HY-16391
    PF-04449913 Inhibitor 99.31%
    PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
  • HY-16582
    LDE225 Diphosphate Antagonist 99.83%
    LDE225 Diphosphate is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
  • HY-12848B
    SAG hydrochloride Agonist
    SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM.
  • HY-13242
    LY2940680 Inhibitor 99.76%
    LY2940680 is an antagonist of the smoothened receptor.
  • HY-N0836
    Jervine Inhibitor 99.03%
    Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
  • HY-13809
    BMS-833923 Inhibitor
    BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.
  • HY-18636
    LEQ506 Inhibitor 98.15%
    LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
  • HY-B0877
    Halcinonide Agonist 99.08%
    Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.
  • HY-100036
    MK-4101 Inhibitor 98.13%
    MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.
  • HY-13459
    PF-5274857 Antagonist
    PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
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