Smo

Related Products

Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation.[3] SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

Smo Related Products (12):

By Effects:	Inhibitors (6) Agonists (2) Antagonists (3) Activators (1)

Cat. No.	Product Name	Effect	Purity

HY-12848

SAG Agonist 99.71%

SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with K_d of 59 nM.

SAG	Agonist	99.71%
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with K_d of 59 nM.

HY-15108

Purmorphamine	Activator	99.89%
Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC₅₀ of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC₅₀ of 1 μM.

HY-16582A

LDE225 Antagonist 99.68%

LDE225 is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
HY-16582

LDE225 Diphosphate Antagonist 99.83%

LDE225 Diphosphate is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
HY-16391

PF-04449913 Inhibitor 99.31%

PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM.
HY-18636

LEQ506 Inhibitor

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.
HY-13242

LY2940680 Inhibitor 99.76%

LY2940680 is an antagonist of the smoothened receptor.

LDE225	Antagonist	99.68%
LDE225 is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

LDE225 Diphosphate	Antagonist	99.83%
LDE225 Diphosphate is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

PF-04449913	Inhibitor	99.31%
PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM.

LEQ506	Inhibitor
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

LY2940680	Inhibitor	99.76%
LY2940680 is an antagonist of the smoothened receptor.

HY-N0836

Jervine	Inhibitor	99.03%
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.

HY-13809

BMS-833923	Inhibitor
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

HY-100036

MK-4101 Inhibitor 98.13%

MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.
HY-B0877

Halcinonide Agonist 99.08%

Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.

MK-4101	Inhibitor	98.13%
MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.

Halcinonide	Agonist	99.08%
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.

HY-13459

PF-5274857	Antagonist
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

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