Smo

Smo Related Products (19):

By Effects:	Inhibitors (7) Agonists (3) Antagonists (7) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-12848

SAG Agonist 99.71%

SAG is a potent Smo receptor agonist which activates the Hedgehog signaling pathway with a K_d of 59 nM.
HY-15108

Purmorphamine Activator 99.89%

Purmorphamine (Shh Signaling Antagonist VI) is a smoothened receptor agonist with an EC₅₀ of 1 μM.
HY-16582A

Erismodegib Antagonist 99.68%

Erismodegib (Sonidegib) is a potent and selective Smoothened (Smo) antagonist with IC₅₀s of 1.3 nM and 2.5 nM for mouse and human Smo, respectively.

SAG	Agonist	99.71%
SAG is a potent Smo receptor agonist which activates the Hedgehog signaling pathway with a K_d of 59 nM.

Purmorphamine	Activator	99.89%
Purmorphamine (Shh Signaling Antagonist VI) is a smoothened receptor agonist with an EC₅₀ of 1 μM.

Erismodegib	Antagonist	99.68%
Erismodegib (Sonidegib) is a potent and selective Smoothened (Smo) antagonist with IC₅₀s of 1.3 nM and 2.5 nM for mouse and human Smo, respectively.

HY-16391

Glasdegib	Inhibitor	99.31%
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM.

HY-12848B

SAG hydrochloride Agonist 99.98%

SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a K_d of 59 nM.

SAG hydrochloride	Agonist	99.98%
SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a K_d of 59 nM.

HY-113965

CUR61414	Inhibitor	>99.0%
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC₅₀ =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a K_i value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.

HY-16582

Erismodegib diphosphate	Antagonist	99.83%
Erismodegib diphosphate (Sonidegib diphosphate) is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

HY-100036

MK-4101	Antagonist	98.31%
MK-4101 is a Smoothened (SMO) antagonist (IC₅₀ of 1.1 µM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC₅₀ of 1.5 µM for mouse cells; IC₅₀ of 1 µM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis.

HY-100224

SANT-1 Antagonist 99.85%

SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.
HY-13242

Taladegib Inhibitor 99.93%

Taladegib (LY2940680) is an antagonist of the smoothened receptor.
HY-B0877

Halcinonide Agonist 99.08%

Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
HY-18636

LEQ506 Inhibitor 98.27%

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.
HY-16587

Saridegib Inhibitor >99.0%

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

SANT-1	Antagonist	99.85%
SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.

Taladegib	Inhibitor	99.93%
Taladegib (LY2940680) is an antagonist of the smoothened receptor.

Halcinonide	Agonist	99.08%
Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.

LEQ506	Inhibitor	98.27%
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

Saridegib	Inhibitor	>99.0%
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-N0836

Jervine	Inhibitor	99.03%
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

HY-12316

20(S)-Hydroxycholesterol	Activator	>98.0%
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells.

HY-117407

ALLO-2	Antagonist	99.58%
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM.

HY-13809

BMS-833923	Inhibitor
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

HY-18287

MRT-83 Antagonist >98.0%

MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

MRT-83	Antagonist	>98.0%
MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

HY-13459

PF-5274857	Antagonist	98.12%
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

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