1. Neuronal Signaling
  2. AChE

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-76299
    Galanthamine Inhibitor 99.78%
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
  • HY-B0034
    Donepezil Hydrochloride Inhibitor 99.97%
    Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine.
  • HY-17552
    sn-Glycero-3-phosphocholine Activator >98.0%
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk.
  • HY-B0942
    Benzethonium chloride Inhibitor >98.0%
    Benzethonium chloride inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes.
  • HY-17368
    Rivastigmine Inhibitor 99.39%
    Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.
  • HY-B0943
    Malathion Inhibitor >98.0%
    Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase, is an insecticide of relatively low human toxicity.
  • HY-B1220
    Metrifonate Inhibitor >98.0%
    Metrifonate is an irreversible organophosphate acetylcholinesterase inhibitor that is used as an insecticide for the control of flies and roaches.
  • HY-16009
    (+)-PHENSERINE Inhibitor
    Posiphen is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.
  • HY-N0342
    Scopoletin Inhibitor 99.57%
    Scopoletin is an inhibitor of acetylcholinesterase (AChE).
  • HY-17388
    (±)-Huperzine A Inhibitor >98.0%
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-N0226A
    Epiberberine chloride Inhibitor 99.60%
    Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
  • HY-14566
    Donepezil Inhibitor 99.87%
    Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
  • HY-B0207A
    Pyridostigmine bromide Inhibitor >98.0%
    Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.
  • HY-A0009
    Galanthamine hydrobromide Inhibitor 99.43%
    Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
  • HY-17387
    (-)-Huperzine A Inhibitor >98.0%
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-11017
    Rivastigmine tartrate Inhibitor 98.53%
    Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase
  • HY-B0949
    Protriptyline hydrochloride Inhibitor 99.91%
    Protriptyline is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.
  • HY-B0732
    Itopride hydrochloride Inhibitor 99.95%
    Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.
  • HY-N0285
    Imperatorin Inhibitor 98.11%
    Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
  • HY-B1200
    Pralidoxime chloride Activator >99.0%
    Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning.
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