1. Neuronal Signaling
  2. AChE

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-76299
    Galanthamine Inhibitor 99.78%
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 500 nM.
  • HY-B0034
    Donepezil Hydrochloride Inhibitor 99.97%
    Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine.
  • HY-17529
    Aldicarb Inhibitor >98.0%
    Aldicarb(OMS771; UC-21149) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.
  • HY-17552
    sn-Glycero-3-phosphocholine Activator >98.0%
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and
  • HY-17387
    (-)-Huperzine A Inhibitor
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-B2244
    Tacrine hydrochloride hydrate Inhibitor 99.98%
    Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
  • HY-B1542A
    Benactyzine hydrochloride Inhibitor 98.74%
    Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM.
  • HY-17368
    Rivastigmine Inhibitor 99.39%
    Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.
  • HY-B0882
    Edrophonium chloride Inhibitor >98.0%
    Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
  • HY-17388
    (±)-Huperzine A Inhibitor >98.0%
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-B0942
    Benzethonium chloride Inhibitor >98.0%
    Benzethonium chloride inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes.
  • HY-A0009
    Galanthamine hydrobromide Inhibitor 99.43%
    Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
  • HY-I0020
    Galanthaminone Inhibitor 99.53%
    Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
  • HY-B0943
    Malathion Inhibitor >98.0%
    Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase, is an insecticide of relatively low human toxicity.
  • HY-N0226A
    Epiberberine chloride Inhibitor 99.60%
    Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
  • HY-B0207A
    Pyridostigmine bromide Inhibitor >98.0%
    Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.
  • HY-B0207AS
    Pyridostigmine D6 bromide Inhibitor
    Pyridostigmine D6 bromide is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.
  • HY-11017
    Rivastigmine tartrate Inhibitor 98.53%
    Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase
  • HY-B0949
    Protriptyline hydrochloride Inhibitor 99.91%
    Protriptyline is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.
  • HY-B0732
    Itopride hydrochloride Inhibitor 99.86%
    Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.