1. Neuronal Signaling
    Epigenetics
    Apoptosis
  2. AChE
    Histone Acetyltransferase
    Apoptosis
  3. Garcinol

Garcinol 

Cat. No.: HY-107569 Purity: >98.0%
Handling Instructions

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.

For research use only. We do not sell to patients.

Garcinol Chemical Structure

Garcinol Chemical Structure

CAS No. : 78824-30-3

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10 mM * 1 mL in DMSO USD 332 In-stock
Estimated Time of Arrival: December 31
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

IC50 & Target

IC50: 0.66 µM (AChE); 7.39 µM (BChE)[1]; 7 μM (HATs); 5 µM (PCAF) [2]

In Vitro

Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner[3].
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells[3].
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner[3].

Cell Proliferation Assay[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Induced apoptosis in HNSCC cells.

Western Blot Analysis[3]

Cell Line: CAL27 cells
Concentration: 50 µM
Incubation Time: 1, 2, 4, 6 hours
Result: Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
In Vivo

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth[3].

Animal Model: Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3]
Dosage: 1 and 2 mg/kg
Administration: I.p.; five times/week for 4 consecutive weeks
Result: Induced significant inhibition of tumor growth.
Molecular Weight

602.80

Formula

C₃₈H₅₀O₆

CAS No.

78824-30-3

SMILES

C/C(C)=C\C[[email protected]@H](C[[email protected]]12C([[email protected]](C(C)([[email protected]@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6589 mL 8.2946 mL 16.5893 mL
5 mM 0.3318 mL 1.6589 mL 3.3179 mL
10 mM 0.1659 mL 0.8295 mL 1.6589 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

GarcinolAChEHistone AcetyltransferaseApoptosisAcetylcholinesteraseHATsHATGarciniaindicaanti-cholinesteraseBChEPCAFanti-inflammatoryanti-cancerInhibitorinhibitorinhibit

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