2. Neuronal Signaling Epigenetics Apoptosis Metabolic Enzyme/Protease
  3. Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
  4. Garcinol

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.

For research use only. We do not sell to patients.

CAS No. : 78824-30-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Garcinol:

Garcinol Related Antibodies

Top Publications Citing Use of Products

    Garcinol purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Dec;334(Pt 2):149016.  [Abstract]

    Rate of blastocyst formation following Garcinol treatment at different concentrations (1, 5, and 10 μM).

    Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352.  [Abstract]

    CCK8 assay results of HUVECs in the Garcinol-treated group.

    Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352.  [Abstract]

    Garcinol (4 μM). Banding and quantitative analysis of VEGFA, VEGFR1 and FGF21 protein expression in different groups.

    Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352.  [Abstract]

    Garcinol (4 μM) reduced the inflammatory response of macrophages to hyperglycemic stimulation. Representative images of iNOS staining and quantitative analysis.

    Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352.  [Abstract]

    Garcinol promotes wound healing in diabetic mice. Representative H&E stained sections of wound samples from the backs of mice in each group on days 7 and 21.

    View All Cholinesterase (ChE) Isoform Specific Products:

    View All Isoforms
    AChE BChE

    View All Histone Acetyltransferase Isoform Specific Products:

    View All Isoforms
    CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

    IC50 & Target

    AChE

     

    BChE

     

    GCN5/PCAF

     

    Cellular Effect
    Cell Line Type Value Description References
    Sf21 IC50
    5 μM
    Compound: 92
    Inhibition of FLAG epitope-tagged recombinant human PCAF expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis
    Inhibition of FLAG epitope-tagged recombinant human PCAF expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis
    		10.1039/C1MD00199J
    Sf21 IC50
    7 μM
    Compound: 92
    Inhibition of His6-tagged recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis
    Inhibition of His6-tagged recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis
    		10.1039/C1MD00199J
    In Vitro

    Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner[3].
    Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells[3].
    Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Garcinol Related Antibodies

    Cell Proliferation Assay[3]

    Cell Line: CAL27 and UMSCC1 cells
    Concentration: 10, 25, 50 µM
    Incubation Time: 24, 48, and 72 hours
    Result: Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

    Apoptosis Analysis[3]

    Cell Line: CAL27 and UMSCC1 cells
    Concentration: 10, 25, 50 µM
    Incubation Time: 24, 48, and 72 hours
    Result: Induced apoptosis in HNSCC cells.

    Western Blot Analysis[3]

    Cell Line: CAL27 cells
    Concentration: 50 µM
    Incubation Time: 1, 2, 4, 6 hours
    Result: Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
    In Vivo

    Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3]
    Dosage: 1 and 2 mg/kg
    Administration: I.p.; five times/week for 4 consecutive weeks
    Result: Induced significant inhibition of tumor growth.
    Molecular Weight

    602.80

    Formula

    C38H50O6
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (82.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6589 mL 8.2946 mL 16.5893 mL
    5 mM 0.3318 mL 1.6589 mL 3.3179 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.85%

    SDS (420 KB)

    COA (256 KB) HNMR (289 KB) LCMS (111 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 1.6589 mL 8.2946 mL 16.5893 mL 41.4731 mL
    5 mM 0.3318 mL 1.6589 mL 3.3179 mL 8.2946 mL
    10 mM 0.1659 mL 0.8295 mL 1.6589 mL 4.1473 mL
    15 mM 0.1106 mL 0.5530 mL 1.1060 mL 2.7649 mL
    20 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
    25 mM 0.0664 mL 0.3318 mL 0.6636 mL 1.6589 mL
    30 mM 0.0553 mL 0.2765 mL 0.5530 mL 1.3824 mL
    DMSO 40 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
    50 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.8295 mL
    60 mM 0.0276 mL 0.1382 mL 0.2765 mL 0.6912 mL
    80 mM 0.0207 mL 0.1037 mL 0.2074 mL 0.5184 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Garcinol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Garcinol78824-30-3Cholinesterase (ChE)Histone AcetyltransferaseApoptosisEndogenous MetaboliteHATsHATGarciniaindicaanti-cholinesteraseBChEPCAFanti-inflammatoryanti-cancerInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Garcinol
    Cat. No.:
    HY-107569
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (420 KB) Français - FR (420 KB) Deutsch - DE (420 KB) Norwegian - NO (420 KB) Español - ES (420 KB) Swedish - SV (420 KB) Italian - IT (420 KB) Korean - KR (420 KB) Portuguese - PT (420 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.