1. Signaling Pathways
  2. Immunology/Inflammation
  3. MyD88


MyD88 (Myeloid differentiation primary response gene 88) is a protein that, in humans, is encoded by the MYD88 gene. Available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few pyogenic bacterial infections, demonstrating a major difference between mouse and human immune responses. MyD88 is an essential adaptor protein in the IL-1R1 signaling pathway. MyD88 may define a family of signal transduction molecules with an ancestral function in the activation of the immune system. MyD88 functions as a pure adaptor linking the IL-1R1 to downstream IRAK kinases. Mutation in MYD88 at position 265 leading to a change from leucine to proline have been identified in many human lymphomas including ABC subtype of Diffuse Large B-cell Lymphoma and Waldenstrom's Macroglobulinemia.

MyD88 Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-50937
    ST 2825 Inhibitor 99.51%
    ST 2825 is a MyD88 dimerization inhibitor.
  • HY-19744
    T6167923 Inhibitor
    T6167923 is a potent MyD88 Toll/IL1 receptor (TIR) domain dimerization inhibitor, which disrupts MyD88 homodimeric formation. T6167923 binds well to the original target and the TIR domains of Mal, TRIF and TRAM. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .
  • HY-N0703
    Schaftoside Inhibitor
    Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
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