IL-1

IL-1 (Interleukin-1) is an inflammatory cytokine. IL-1 family comprises a total of 11 members, 7 ligands with agonist activity (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and four members with antagonistic activities (IL-1Ra, IL-36Ra, IL-37, IL-38)[1]. Il-1 can be used as a leukocytic pyrogen, a mediator of fever and a leukocytic endogenous mediator, and an inducer of several components of the acute-phase response and lymphocyte-activating factor, shows activity in myriad immunological responses, spanning both innate and adaptive immunity[2].