CD171/L1CAM
CD171, the L1 cell adhesion molecule, is a neuronal member of the L1 branch of the immunoglobulin superfamily alongside NCAM, neurofascin and NrCAM. Its extracellular region combines six Ig-like domains and five fibronectin type III repeats that mediate both homophilic and heterophilic adhesion with partners including integrins. L1CAM guides axon outgrowth and fasciculation during neural development, and mutations in its X-linked gene cause the spectrum of CRASH syndromes encompassing corpus callosum hypoplasia, hydrocephalus and spastic paraplegia. Aberrant re-expression in endometrial, ovarian and pancreatic carcinomas promotes invasion, and CD171 is being developed as a therapeutic target with antibody and CAR-T approaches.
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CD171/L1CAM Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
