2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Angiopoietins

Angiopoietins

Angiopoietins

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Angiopoietins are a family of vascular growth factors that bind to TIE (Tyr kinase with Ig and epidermal growth factor homology domains) receptors. The growth factors ANG1, ANG2 and ANG4 (the human orthologue of mouse ANG3) are ligands for TIE2, whereas TIE1 remains an orphan receptor which is able to heterodimerize with TIE2 and to modulate TIE2 signal transduction. The Ang/Tie pathway plays an important role in the regulation of vascular stability, in angiogenesis under physiological and pathological conditions, as well as in inflammation. Under physiological conditions, ANG1 binds to and phosphorylates the TIE2 receptor, leading to downstream signalling that promotes cell survival and vascular stability. ANG2 is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A).

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72828
    Angiopoietin-2 Protein, Human (CHO, His)

    Angiopoietin-2; ANG-2; ANGPT2

    		Human CHO
  • HY-P72829
    Angiopoietin-2 Protein, Human (496a.a, HEK293, His)

    Angiopoietin-2; ANG-2; ANGPT2

    		Human HEK293
  • HY-P72830
    Angiopoietin-2 Protein, Mouse (HEK293, His)

    Angiopoietin-2; ANG-2; ANGPT2

    		Mouse HEK293
  • HY-P78059
    ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi)

    ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like Protein 3

    		Human HEK293
  • HY-P78061
    Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi)

    AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand

    		Human HEK293
  • HY-P78381
    Angiopoietin-2 Protein, Human (HEK293, His-Avi)

    AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand

    		Human HEK293
  • HY-P71362
    TIE-1 Protein, Human (HEK293, His)

    Tyrosine-Protein Kinase Receptor Tie-1; TIE1; TIE

    		Human HEK293
  • HY-P70061
    Angiopoietin-1 Protein, Human (HEK293, Fc)

    rHuAngiopoietin-1/ANG1, Fc; AGP1; AGPT; Ang1; ANG-1; angiopoietin 1; Angiopoietin-1; ANGPT1

    		Human HEK293
    Angiopoietin-1 Protein, Human (HEK 293, Fc) is a recombinant Angiopoietin-1 protein with a Fc-flag. Angiopoietin-1 Protein is a secretory ligand of tyrosine kinase that is mainly expressed by vascular endothelial cells and hematopoietic cells. Angiopoietin-1 (Ang1) is a potential growth factor for therapeutic angiogenesis and vascular stabilization.
  • HY-P7844
    Angiopoietin-2 Protein, Mouse (HEK293, Fc)

    rMuAngiopoietin-2/ANG2, Fc ; AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand

    		Mouse HEK293
  • HY-P7508
    ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, Fc)

    rMuAngiopoietin-Related Protein 4, C-Fc; ANGPTL4; Angiopoietin-Related Protein 4

    		Mouse HEK293
    Angiopoietin-related protein 4/ANGPTL4 Protein, Mouse (HEK293, Fc) expresses in HEK293 with an Fc fragment at the C-terminus. Angiopoietin-Related Protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation.
  • HY-P7507
    ANGPTL4/Angiopoietin-related 4 Protein, Human

    rHuAngiopoietin-Related Protein 4, His; ANGPTL4; Angiopoietin-Related Protein 4

    		Human HEK293
    Angiopoietin-like protein 4, Human modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). Angiopoietin-Related Protein 4 is a conventional, non-competitive inhibitor that binds to LPL to prevent the hydrolysis of substrate as part of reversible mechanism.
  • HY-P7510
    Angiopoietin-2 Protein, Human (222a.a, HEK293, His)

    rHuAngiopoietin-2, His; ANGPT2; ANG2; Angiopoietin-2

    		Human HEK293
    Angiopoietin-2 Protein, Human (222a.a, HEK293, His) is a circulating antagonistic ligand of the endothelial-specific Tie2 receptor and has been identified as an important gatekeeper of endothelial activation.
  • HY-P7506
    ANGPTL8/Angiopoietin-like 8 Protein, Human (HEK293, Fc)

    rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8

    		Human HEK293
    ANGPTL 8 Protein, Human (HEK293, Fc) is a secreted inhibitor of LPL. Angiopoietin-like Protein 8 may function as an important metabolic switch, by forming complexes with ANGPTL3, or with ANGPTL4, in order to direct the flow of energy from triglycerides in blood according to the needs of the body.
  • HY-P7505
    ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His)

    rHuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3

    		Human HEK293
    ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His) plays an important role in lipoprotein metabolism. Angiopoietin-like Protein 3 acts as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL). Angiopoietin-like Protein 3 inhibits endothelial lipase hydrolysis of HDL-phospholipid (PL), thereby increasing HDL-PL levels.
  • HY-P70123
    Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc)

    rRhANG2, Fc; AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand

    		Rhesus Macaque HEK293
  • HY-P72450
    TIE-2 Protein, Human (723a.a, HEK293, His)

    Angiopoietin-1 receptor; CD202b antigen; CD202b; hTIE2; p140 TEK; TEK; Tie2; Tie-2; VMCM; VMCM1

    		Human HEK293
  • HY-P74412
    Angiopoietin-1 Protein, Mouse (HEK293, His)

    AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1

    		Mouse HEK293
  • HY-P7504
    ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His)

    rMuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3

    		Mouse HEK293
    ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His) is a mouse recombinant ANGPTL3 with a 10-His tag at the C-terminus. Angiopoietin-like Protein 3, Mouse (HEK293, His) is produced by Mammalian expression system and the target gene encoding Ser17-Thr455 is expressed.
  • HY-P7509
    ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His)

    rHuAngiopoietin-related Protein 7, His; ANGPTL7; Angiopoietin-related Protein 7

    		Human HEK293
    ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His) regulates angiogenesis, and promotes the expansion and repopulation of human hematopoietic stem cells and progenitor cells through the Wnt signaling pathway. Angiopoietin-related Protein 7 is a pro-inflammatory effector that induces inflammatory responses in macrophages through the P38 MAPK signaling pathway.
  • HY-P77295
    ANGPTL1 Protein, Canine (HEK293, Fc)

    Angiopoietin like 1; ANGPTL1; ANG-3

    		Canine HEK293
Cat. No. Product Name Effect Purity