1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokine Receptor

CC chemokine (or β-chemokine) subfamily is one of the largest subfamilies of chemokines composed of 28 chemotactic cytokine ligands (CCL1-28). The chemokine ligands are defined based on the positioning of their initial cysteine residues. Thus, CC chemokine ligands (CCLs) have two adjoining amino-terminal cysteine residues. Actually, among them, CCL9 and CCL10 denote the same chemokine. All these chemokines are ligands for 10 receptors-CC motif chemokine receptors (CCR)1-10. Just like the rest of chemokines, CC chemokines are crucial for the functioning of the immune system cells.

Cat. No. Product Name / Synonyms Species Source
  • HY-P700540
    CCR5 Protein, Mouse (P. pastoris, His)

    CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5, CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003;

    Mouse P. pastoris
    CCR5 Protein, a receptor for inflammatory CC-chemokines, including CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, plays a crucial role in signal transduction by increasing intracellular calcium ion levels. It contributes to granulocytic lineage control and T-lymphocyte migration to infection sites, serving as a chemotactic receptor. Interactions with PRAF2, GRK2, ARRB1, ARRB2, and CNIH4 highlight CCR5's regulatory network complexity. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation, and sialic acid modifications. Glycosylation on Ser-6 is essential for optimal CCL4 binding. The stimulating effect on T-lymphocyte chemotaxis, observed in interaction with S100A4, emphasizes CCR5's multifaceted roles in immune responses and cellular signaling pathways. CCR5 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived CCR5 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of CCR5 Protein, Mouse (P. pastoris, His) is 92 a.a., with molecular weight of 12.6 kDa.
  • HY-P700399
    CCR4 Protein-VLP, Human (HEK293, His)

    CCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD antigen CD194

    Human HEK293
    CCR4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.
  • HY-P700400
    CCR8 Protein-VLP, Human (HEK293, His)

    CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973

    Human HEK293
    CCR8 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.
  • HY-P77589
    CCR2b Protein-VLP, Human (HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    Human HEK293
    CCR2b Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.
  • HY-P77590
    CCR2b Protein-VLP, Human (Biotinylated, HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    Human HEK293
    CCR2b Protein-VLP, Human (Biotinylated, HEK293) is available in solution form, no concentration information, recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay.
  • HY-P700965
    CCR8 Protein, Cynomolgus (HEK293, mFc)

    CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198

    Cynomolgus HEK293
    CCR8 is part of the G-protein coupled receptor 1 family. CCR8 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived CCR8 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CCR8 Protein, Cynomolgus (HEK293, mFc) is 35 a.a., with molecular weight of 35-45 kDa.
  • HY-P700378
    ACKR2 Protein, Human (Cell-Free, His)

    ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250;

    Human E. coli Cell-free
    ACKR2 Protein, an atypical chemokine receptor, controls chemokine levels and localization with high-affinity binding. Operating independently, ACKR2, also known as an interceptor or decoy receptor, interacts with diverse chemokines, triggering a beta-arrestin 1-dependent signaling pathway. This pathway facilitates ACKR2 relocation, enhancing efficiency in chemokine uptake and degradation. Scavenging chemokines in various tissues, ACKR2 plays a pivotal role in resolving inflammation, regulating adaptive immune responses, and influencing leukocyte interactions with lymphatic endothelial cells. ACKR2 contributes significantly to immune silencing of macrophages during inflammation resolution. ACKR2 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR2 Protein, Human (Cell-Free, His) is 384 a.a., with molecular weight of 46.9 kDa.
  • HY-P700541
    CCR2 Protein, Mouse (N-His, C-Myc)

    CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2

    Mouse E. coli
    CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of CCR2 Protein, Mouse (N-His, C-Myc) is 55 a.a., with molecular weight of 13.6 kDa.
  • HY-P700542
    CCR8 Protein, Human (Cell-Free, His)

    CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973

    Human E. coli Cell-free
    CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (Cell-Free, His) is the recombinant human-derived CCR8 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of CCR8 Protein, Human (Cell-Free, His) is 56 a.a., with molecular weight of 9.4 kDa.
  • HY-P700543
    CCR8 Protein, Human (P. pastoris, His)

    CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973

    Human P. pastoris
    CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris, with C-Myc, C-6*His labeled tag. The total length of CCR8 Protein, Human (P. pastoris, His) is 35 a.a., with molecular weight of 7.7 kDa.
  • HY-P700544
    CCR9 Protein, Human (GST)

    chemokine (C-C motif) receptor 9; GPR28; C-C chemokine receptor type 9; CDw199; GPR 9 6; G protein-coupled receptor 28; GPR-9-6; CC-CKR-9;

    Human E. coli
    CCR9 Protein, a receptor for SCYA25/TECK, activates signaling, elevating intracellular calcium ions. In microbial infection, it acts as an alternative HIV-1 coreceptor with CD4, influencing the infection process. CCR9 Protein, Human (GST) is the recombinant human-derived CCR9 protein, expressed by E. coli, with N-GST labeled tag. The total length of CCR9 Protein, Human (GST) is 48 a.a., with molecular weight of 31.9 kDa.
  • HY-P702232
    CCR1 Protein, Mouse (Cell-Free, His)

    C-C chemokine receptor type 1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R

    Mouse E. coli Cell-free
    CCR1 Protein, a C-C chemokine receptor, binds MIP-1-alpha, RANTES, and, to a lesser extent, MIP-1-beta or MCP-1, initiating signal transduction and elevating intracellular calcium levels. This receptor is crucial in modulating stem cell proliferation, regulating processes vital for tissue homeostasis and immune responses. CCR1's interaction with CREB3 suggests its involvement in complex signaling networks governing cellular functions. CCR1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CCR1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR1 Protein, Mouse (Cell-Free, His) is 355 a.a., with molecular weight of 43.7 kDa.
  • HY-P702233
    CCR5 Protein, Human (Cell-Free, His)

    C-C chemokine receptor type 5; CHEMR13; HIV-1 fusion coreceptor

    Human E. coli Cell-free
    CCR5 Protein, a receptor for inflammatory CC-chemokines like CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, transduces signals, elevating intracellular calcium levels. It regulates granulocytic lineage and facilitates T-lymphocyte migration to infection sites. In microbial infection, CCR5 acts as a coreceptor, along with CD4, for HIV-1, emphasizing its role in the cellular response to infections. CCR5 Protein, Human (Cell-Free, His) is the recombinant human-derived CCR5 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR5 Protein, Human (Cell-Free, His) is 352 a.a., with molecular weight of 43.9 kDa.
  • HY-P702234
    CCR6 Protein, Human (Cell-Free, His)

    C-C chemokine receptor type 6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor

    Human E. coli Cell-free
    The CCR6 protein is a receptor for CCL20 and increases intracellular calcium levels upon ligand binding. Notably, CCR6 also acts as a receptor for non-chemokine ligands such as β-defensins (DEFB1, DEFB4, DEFB4A/B). CCR6 Protein, Human (Cell-Free, His) is the recombinant human-derived CCR6 protein, expressed by E. coli Cell-free , with N-6*His labeled tag. The total length of CCR6 Protein, Human (Cell-Free, His) is 374 a.a., with molecular weight of 46.5 kDa.
  • HY-P702235
    CCR6 Protein, Human (Cell-Free, His, SUMO)

    C-C chemokine receptor type 6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor

    Human E. coli Cell-free
    The CCR6 protein is a receptor for CCL20 and increases intracellular calcium levels upon ligand binding. Notably, CCR6 also acts as a receptor for non-chemokine ligands such as β-defensins (DEFB1, DEFB4, DEFB4A/B). CCR6 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived CCR6 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of CCR6 Protein, Human (Cell-Free, His, SUMO) is 374 a.a., with molecular weight of 58.5 kDa.
  • HY-P702236
    CCR8 Protein, Macaca fascicularis (Cell-Free, His, SUMO)

    C-C chemokine receptor type 8; CCR-8

    Cynomolgus E. coli Cell-free
    CCR8 is part of the G-protein coupled receptor 1 family. CCR8 Protein, Macaca fascicularis (Cell-Free, His, SUMO) is the recombinant cynomolgus-derived CCR8 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of CCR8 Protein, Macaca fascicularis (Cell-Free, His, SUMO) is 355 a.a., with molecular weight of 54.0 kDa.
  • HY-P702237
    CCR8 Protein, Mouse (Cell-Free, His)

    C-C chemokine receptor type 8; CD_antigen: CDw198 Cmkbr8; Ter1; C-C CKR-8; CC-CKR-8; CCR-8

    Mouse E. coli Cell-free
    The CCR8 protein serves as a receptor for the CCL1/SCY1/TCA-3 chemokine and is critical for mediating cellular responses. Its interaction with CCL1 coordinates key chemotactic signaling that regulates immune cell migration and positioning in the cellular microenvironment. CCR8 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CCR8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR8 Protein, Mouse (Cell-Free, His) is 353 a.a., with molecular weight of 41.5 kDa.
  • HY-P702238
    CCR8 Protein, Rhesus Macaque (Cell-Free, His)

    C-C chemokine receptor type 8; CD_antigen: CDw198 Cmkbr8; Ter1; C-C CKR-8; CC-CKR-8; CCR-8

    Rhesus Macaque E. coli Cell-free
    CCR8 Protein acts as a receptor for chemokines CCL1/SCYA1/I-309, possibly influencing monocyte chemotaxis and thymic cell line apoptosis, as indicated by similarity-based analyses. CCR8 Protein, Rhesus Macaque (Cell-Free, His) is the recombinant Rhesus Macaque-derived CCR8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR8 Protein, Rhesus Macaque (Cell-Free, His) is 356 a.a., with molecular weight of 42.7 kDa.
  • HY-P702594
    CCR6 Protein-VLP, Human (HEK293, His)

    C-C chemokine receptor type 6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor

    Human HEK293
    CCR6 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.
  • HY-P702597
    CCR9 Protein-VLP, Human (HEK293, His)

    chemokine (C-C motif) receptor 9; GPR28; C-C chemokine receptor type 9; CDw199; GPR 9 6; G protein-coupled receptor 28; GPR-9-6; CC-CKR-9;

    Human HEK293
    CCR9 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.
Cat. No. Product Name Effect Purity