CCR2b Protein-VLP, Human (Biotinylated, HEK293)

CCR2b Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

The CCR2b Protein-VLP serves as a crucial functional receptor for CCL2 and can also bind to CCL7 and CCL12. Its interaction with CCL2 on monocytes and macrophages facilitates chemotaxis and induces migration by activating the PI3K cascade, small G protein Rac, and lamellipodium protrusion. Additionally, it acts as a receptor for the beta-defensin DEFB106A/DEFB106B and regulates the expression of T-cell inflammatory cytokines, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. CCR2b facilitates the export of mature thymocytes by enhancing directional movement in response to sphingosine-1-phosphate stimulation and up-regulating S1P1R expression through JAK-STAT signaling. It plays a crucial role in mediating neuropathic pain induced by peripheral nerve injury and increases NMDA-mediated synaptic transmission in dopamine D1 and D2 receptor-containing neurons. Furthermore, CCR2b is involved in the recruitment of macrophages and monocytes to the injury site following brain injury. In the context of microbial infection, it serves as an alternative coreceptor with CD4 for HIV-1 infection.

Human

HEK293

Tag Free

P41597-2 (M1-L360)

729230  [NCBI]

Full Length of Isoform-2

Biotin

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFFRKHITKRFCKQCPVFYRETVDGVTSTNTPSTGEQEVSAGL

≥ 95%, as determined by HPLC.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4. Notice: If you need it for immunization, Do Not use any adjuvant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.