EBI2/GPR183
The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.
EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.
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EBI2/GPR183 Related Products (14)
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7α,25-Dihydroxycholesterol
0 ImagesSynonyms: 7α,25-OHC7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells. -
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NIBR189
0 ImagesNIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases. -
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GSK682753A
0 ImagesGSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. -
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7α,27-Dihydroxycholesterol
0 Images7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC). -
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SAE-14
0 ImagesSynonyms: GPR183 antagonist-1SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. -
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ML401
0 ImagesML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity. -
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GPR183 antagonist-3
0 ImagesGPR183 antagonist-3 (compound 33) is an oral active GPR183 antagonist with the IC50 of 8.7 μM. GPR183 antagonist-3 displays strong in vitro antimigration and anti-inflammatory activity in monocytes, and improves the pathological symptoms of DSS-induced experimental colitis. -
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7α,25-Dihydroxycholesterol-d6
0 ImagesCat. No.: HY-113962SCAS No.: 2260669-11-0Synonyms: 7α,25-OHC-d67α,25-Dihydroxycholesterol-d6 is deuterium labeled 7α,25-Dihydroxycholesterol. 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly -
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Gpr183 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS05692Gpr183 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr183 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Gpr183 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS05691Gpr183 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr183 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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GPR183 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS05690GPR183 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR183 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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GPR183 inverse agonist-1
0 ImagesCat. No.: HY-175306CAS No.: 2380033-51-0GPR183 inverse agonist-1 (Compound 78) is a GPR183 inverse agonist. GPR183 inverse agonist-1 inhibits the GPR183-mediated Gi activation and β-arrestin2 recruitment, and blocks PBMC migration. GPR183 inverse agonist-1 can be used for inflammatory, autoimmune and neoplastic disorders research. -
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GSK682753A (Standard)
0 ImagesGSK682753A (Standard) is the analytical standard of GSK682753A (HY-101192). This product is intended for research and analytical applications. GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. -
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7α,25-Dihydroxycholesterol intermediate-1
0 ImagesCat. No.: HY-400897CAS No.: 1326612-12-77α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs. -
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