1. Signaling Pathways
  2. GPCR/G Protein
  3. EBI2/GPR183

EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

EBI2/GPR183 Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-101192
    GSK682753A Inhibitor 98.47%
    GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
  • HY-12336
    NIBR189 Antagonist 99.24%
    NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).
  • HY-116814
    ML401 Antagonist
    ML401 is a probe and a potent, selective EBI2 (also known as GPR183) antagonist with an IC50 of 1.02 nM. ML401 displays activity in a chemotaxis assay (IC50=6 nM).
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