1. GPCR/G Protein
  2. EBI2/GPR183


Cat. No.: HY-101192 Purity: 98.47%
Handling Instructions

GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.

For research use only. We do not sell to patients.
GSK682753A Chemical Structure

GSK682753A Chemical Structure

CAS No. : 1334294-76-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
5 mg USD 156 In-stock
10 mg USD 264 In-stock
25 mg USD 576 In-stock
50 mg USD 996 In-stock
100 mg USD 1680 In-stock
200 mg   Get quote  
500 mg   Get quote  

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GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.

IC50 & Target

IC50: 53.6 nM (EBI2)[1]

In Vitro

GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC50of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency[1].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0843 mL 10.4214 mL 20.8429 mL
5 mM 0.4169 mL 2.0843 mL 4.1686 mL
10 mM 0.2084 mL 1.0421 mL 2.0843 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay

The effect of GSK682753A on cAMP-induced CREB activation is measured. GSK682753A at varying concentrations is added when the transfection is stopped with a DMSO concentration after compound addition of 0.1%. The CREB activity is determined 24 h after transfection using the LucLite substrate[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 27 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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