1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear Receptor Superfamily
  4. Estrogen Receptor

Estrogen Receptor

Estrogen receptors (ERs) includes the nuclear receptor (NR) family (ERα and ERβ) and membrane estrogen receptors (mERs; G protein-coupled receptor 30 (GPR30)). Noteworthy, ERs are generally referred to as ERα (NR3A1) and ERβ (NR3A2). ERs (ERα and ERβ) act as ligand-activated transcription factors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Like others members of NRs, ERs contain evolutionarily conserved structurally and functionally distinct domains: N- terminal (NTD, A/B domains, AF-1), DNA binding domain (DBD, C domain), the hinge (D domain), the C-terminal region containing the ligand binding domain (LBD, E/F domain, AF-2). The two ERs share a high degree of sequence homology except in their NH2-terminal domains, and they have similar affinities for E2 and bind the same DNA response elements.

Cat. No. Product Name / Synonyms Species Source
  • HY-P70248
    ER alpha/ESR1 Protein, Human (His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    Human E. coli
  • HY-P70791
    ER beta/ESR2 Protein, Human (His)

    Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2

    Human E. coli
Cat. No. Product Name Effect Purity