2. Recombinant Proteins
  3. Receptor Proteins
  4. Nuclear Receptor Superfamily
  5. Estrogen Receptor

Estrogen Receptor

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Estrogen receptors (ERs) includes the nuclear receptor (NR) family (ERα and ERβ) and membrane estrogen receptors (mERs; G protein-coupled receptor 30 (GPR30)). Noteworthy, ERs are generally referred to as ERα (NR3A1) and ERβ (NR3A2). ERs (ERα and ERβ) act as ligand-activated transcription factors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Like others members of NRs, ERs contain evolutionarily conserved structurally and functionally distinct domains: N- terminal (NTD, A/B domains, AF-1), DNA binding domain (DBD, C domain), the hinge (D domain), the C-terminal region containing the ligand binding domain (LBD, E/F domain, AF-2). The two ERs share a high degree of sequence homology except in their NH2-terminal domains, and they have similar affinities for E2 and bind the same DNA response elements.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70248
    ER alpha/ESR1 Protein, Human (His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    		Human E. coli
    The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ER alpha/ESR1 Protein, Human (His) is 116 a.a., with molecular weight of 12-14 kDa.
  • HY-P70791
    ER beta/ESR2 Protein, Human (His)

    Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2

    		Human E. coli
    ER beta/ESR2 Protein, a nuclear hormone receptor, binds estrogens akin to ESR1/ER-alpha. It activates estrogen-dependent reporter genes with ERE. However, it lacks ligand binding ability and exhibits minimal ERE binding, resulting in the loss of ligand-dependent transactivation ability. ER beta/ESR2 Protein, Human (His) is the recombinant human-derived ER beta/ESR2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ER beta/ESR2 Protein, Human (His) is 323 a.a., with molecular weight of 35-40 kDa.
Cat. No. Product Name Effect Purity