Estrogen Receptor
Estrogen receptors (ERs) includes the nuclear receptor (NR) family (ERα and ERβ) and membrane estrogen receptors (mERs; G protein-coupled receptor 30 (GPR30)). Noteworthy, ERs are generally referred to as ERα (NR3A1) and ERβ (NR3A2). ERs (ERα and ERβ) act as ligand-activated transcription factors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Like others members of NRs, ERs contain evolutionarily conserved structurally and functionally distinct domains: N- terminal (NTD, A/B domains, AF-1), DNA binding domain (DBD, C domain), the hinge (D domain), the C-terminal region containing the ligand binding domain (LBD, E/F domain, AF-2). The two ERs share a high degree of sequence homology except in their NH2-terminal domains, and they have similar affinities for E2 and bind the same DNA response elements.
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Estrogen Receptor Recombinant Proteins (2)
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Inhibitors & Agonists (799)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
