CD158d/KIR2DL4
CD158d (KIR2DL4) is an atypical member of the killer-cell immunoglobulin-like receptor family that defies the usual activating-versus-inhibitory dichotomy: it carries cytoplasmic ITIM motifs yet also has a charged transmembrane residue that recruits the FcR gamma adaptor. Unlike most KIR genes, KIR2DL4 is present and stably expressed on virtually all natural killer cells, and its ligand is the nonclassical HLA-G molecule characteristic of fetal trophoblast. The receptor resides largely in endosomal compartments and signals from there to promote chemokine and proangiogenic cytokine production rather than cytotoxicity. Through this pathway KIR2DL4 is implicated in remodeling of the maternal-fetal interface and has been studied in recurrent miscarriage and pre-eclampsia.
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CD158d/KIR2DL4 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
