IREM-1/CD300f
IREM-1, formally CD300f, is an inhibitory receptor of the CD300 family expressed mainly on monocytes, macrophages and dendritic cells. Its cytoplasmic tail contains ITIM motifs that recruit SHP-1 and SHP-2, and receptor engagement dampens responses to Fc receptor and Toll-like receptor stimulation, restraining inflammatory cytokine output. The extracellular domain adopts an IgV-like fold similar to other CD300 members, some of which recognize phospholipid ligands such as phosphatidylserine. By counterbalancing activating members of the cluster, IREM-1 contributes to the paired-receptor architecture that governs myeloid cell activation thresholds, and it is a subject of interest in inflammatory disease models.
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IREM-1/CD300f Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
