1. GPCR/G Protein
  2. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-16168A
    Degarelix Antagonist 99.92%
    Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
  • HY-13665
    Leuprolide Acetate Agonist 99.88%
    Leuprolide acetate (Leuprorelin) is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.
  • HY-17405
    Alarelin Acetate Agonist 99.61%
    Alarelin acetate is a synthetic GnRH agonist.
  • HY-P0009A
    Cetrorelix Acetate Antagonist 98.88%
    Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence: N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2.
  • HY-12551
    Triptorelin Agonist 98.44%
    Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation In vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles.
  • HY-13673A
    Goserelin acetate Agonist 99.96%
    Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).
  • HY-13534
    Abarelix Antagonist 98.11%
    Abarelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
  • HY-12556
    Deslorelin Agonist 99.94%
    Deslorelin is a GnRH agonist.
  • HY-13581A
    Buserelin Acetate Agonist 99.98%
    Buserelin (INN) Acetate is a gonadotropin-releasing hormone agonist (GnRH agonist).
  • HY-16474
    Relugolix Antagonist >98.0%
    Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.
  • HY-14789
    Elagolix Antagonist 98.06%
    Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).
  • HY-P0057
    Nafarelin Agonist 98.99%
    Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2.
  • HY-P0051
    Lecirelin Agonist
    Lecirelin is a synthetic GnRH (gonadotropin releasing hormone) analogue which shows a great efficacy in the treatment of bovine ovarian follicular cysts. Sequence: {Glp}-His-Trp-Ser-Tyr-Val-Leu-Arg-Pro.
  • HY-12555
    Gonadorelin acetate Agonist 98.74%
    Gonadorelin acetate is a man-made protein that is like a hormone in the body called gonadotropin-releasing hormone (GnRH).
  • HY-13673
    Goserelin Agonist
    Goserelin(ICI 118630) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).
  • HY-14369
    Elagolix sodium Antagonist 99.20%
    Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
  • HY-12553
    Leuprorelin Agonist
    Leuprolide is an agonist at pituitary GnRH receptors.
  • HY-U00289
    opigolix Antagonist
    Opigolix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.
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