1. Signaling Pathways
  2. GPCR/G Protein
  3. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-16168A
    Degarelix Antagonist 99.92%
    Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
  • HY-13665
    Leuprolide Acetate Agonist 99.88%
    Leuprolide acetate (Leuprorelin acetate) is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids.
  • HY-13581A
    Buserelin Acetate Agonist 99.50%
    Buserelin Acetate is a gonadotropin-releasing hormone agonist (GnRH agonist).
  • HY-P0009A
    Cetrorelix Acetate Antagonist 99.69%
    Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
  • HY-17405
    Alarelin Acetate Agonist 99.61%
    Alarelin acetate is a synthetic GnRH agonist.
  • HY-133080
    BAY-784 Antagonist
    BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
  • HY-16474
    Relugolix Antagonist >98.0%
    Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.
  • HY-14369
    Elagolix sodium Antagonist 99.66%
    Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
  • HY-13673A
    Goserelin acetate Agonist 99.96%
    Goserelin acetate (ICI 118630 acetate) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).
  • HY-13534
    Abarelix Antagonist
    Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
  • HY-14789
    (R)-Elagolix Antagonist 98.06%
    Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).
  • HY-P0051
    Lecirelin Agonist 99.80%
    Lecirelin is a synthetic GnRH (gonadotropin releasing hormone) analogue which shows a great efficacy in the treatment of bovine ovarian follicular cysts.
  • HY-13534A
    Abarelix Acetate Antagonist 99.62%
    Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.
  • HY-13673
    Goserelin Agonist
    Goserelin(ICI 118630) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).
  • HY-U00289
    opigolix Antagonist
    Opigolix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.
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