GUB10194

Cat. No.: HY-P11811: Data Sheet Handling Instructions
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GUB10194 is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 does not significantly affect body weight or food intake.

For research use only. We do not sell to patients.

GUB10194 Chemical Structure

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•Related Small Molecules:

•Related Proteins:

View All Neuropeptide FF Receptor Isoform Specific Products:

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NPFFR1 NPFFR2

Biological Activity
Purity & Documentation
References
Customer Review

Description

GUB10194 is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 does not significantly affect body weight or food intake^[1].

IC₅₀ & Target^[1]

NPFF2-R

> 5000 nM (EC₅₀)

In Vitro

GUB10194 (30 min) acts as a full, GPR10-selective agonist in Chem-1 cells expressing GPR10 (EC₅₀ = 15 nM), with no activity detected in CHO-K1 cells expressing NPFF2R (EC₅₀ > 5000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GUB10194 (1250 nmol/kg; s.c.; twice daily) does not produce significant body weight loss or food intake inhibition in diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (male, 5 weeks old at purchase, diet-induced obese)^[1]
Dosage:	1250 nmol/kg
Administration:	s.c.; twice daily
Result:	Did not significantly influence body weight or food intake during treatment or wash-out period. Was detected in plasma samples collected 4 hours after the last dose on treatment day 6.

Molecular Weight

1874.23

Formula

C₈₅H₁₄₈N₂₄O₂₃

Sequence

Ser-Arg-Gly-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-Arg-Pro-Val-Gly-Arg-Phe-NH2

Sequence Shortening

SRG-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-RPVGRF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alexopoulou F, et al. Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect. Sci Rep. 2022;12(1):1696. Published 2022 Feb 1. [Content Brief]

GUB10194 Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GUB10194GUB 10194GUB-10194GnRH ReceptorNeuropeptide FF ReceptorGonadotropin releasing hormone receptorGNRHRNPFF2 receptorhuman GPR10-expressing Chem-1 cellsGPR10G-protein coupled receptor 10human NPFF2R-expressing CHO-K1 cellsdiet-induced obese miceInhibitorinhibitorinhibit

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