1. Immunology/Inflammation
  2. NO Synthase

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-18729A
    L-NAME hydrochloride Inhibitor >98.0%
    L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
  • HY-18731
    1400W Dihydrochloride Inhibitor >98.0%
    1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.
  • HY-N0455A
    L-Arginine hydrochloride Activator >98.0%
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
  • HY-12119
    GW274150 Inhibitor 99.84%
    GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.
  • HY-N0043
    Ginsenoside Rd Inhibitor >98.0%
    Ginsenoside Rd is one of the most abundant ingredients of Panax ginseng. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx.
  • HY-B1581A
    L-Canavanine sulfate Inhibitor >98.0%
    L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
  • HY-U00432
    S-MTC Inhibitor
    S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.
  • HY-B2141
    Bendazol Activator 99.45%
    Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.
  • HY-N0041
    Ginsenoside Rb3 Inhibitor >99.0%
    Ginsenoside Rb3 is extracted from steamed Panax notoginseng. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
  • HY-B2162
    Chondroitin sulfate
    Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
  • HY-19504
    AVE-3085 Activator
    AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.
  • HY-N0455
    L-Arginine Activator
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
  • HY-101238
    Agmatine sulfate Inhibitor >98.0%
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
  • HY-102015
    6-Biopterin 98.02%
    6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
  • HY-12116
    L-NIL Inhibitor 99.26%
    L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 3.3 and 92 μM for mouse inducible NO synthase and rat brain constitutive NO synthase, respectively.
  • HY-N2300
    Kuwanon A Inhibitor
    Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
  • HY-107383
    Tetrahydrobiopterin 98.63%
    Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.