N-Phthaloyl-L-glutamic acid
Based on 1 Customer Validation
N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 340-90-9
- Formula: C13H11NO6
- Molecular Weight:277.23
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
N-Phthaloyl-L-glutamic acid (compound 2f) (25-50 μg/mL; 72 h) inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production and shows low cytotoxicity against spleen cell BALB/c mice[1].
N-Phthaloyl-L-glutamic acid (25 μg/mL; 48 h) exhibits weak antiproliferative activity against MDA/MB-435, HCT-8, and SF-295 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA/MB-435, HCT-8, SF-295
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Concentration:25 μg/mL
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Incubation Time:48 h
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Result:Inhibited proliferation of MDA/MB-435 cells by 12.92%, HCT-8 cells by 6.52%, and SF-295 cells by 14.42%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (weight 25-30 g) (carrageenan-induced air pouch model)[1]
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Dosage:100 mg/kg
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Administration:p.o.; single dose
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Result:Reduced polymorphonuclear leukocyte migration into the air pouch, resulting in 61.7% inhibition of PMNL infiltration.
Chemical Information
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CAS No. 340-90-9
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Appearance Solid
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Molecular Weight 277.23
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Formula C13H11NO6
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SMILES
[C@H](CCC(O)=O)(C(O)=O)N1C(=O)C=2C(C1=O)=CC=CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 116.67 mg/mL (420.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6071 mL | 18.0356 mL | 36.0711 mL | 90.1778 mL |
| 5 mM | 0.7214 mL | 3.6071 mL | 7.2142 mL | 18.0356 mL | |
| 10 mM | 0.3607 mL | 1.8036 mL | 3.6071 mL | 9.0178 mL | |
| 15 mM | 0.2405 mL | 1.2024 mL | 2.4047 mL | 6.0119 mL | |
| 20 mM | 0.1804 mL | 0.9018 mL | 1.8036 mL | 4.5089 mL | |
| 25 mM | 0.1443 mL | 0.7214 mL | 1.4428 mL | 3.6071 mL | |
| 30 mM | 0.1202 mL | 0.6012 mL | 1.2024 mL | 3.0059 mL | |
| 40 mM | 0.0902 mL | 0.4509 mL | 0.9018 mL | 2.2544 mL | |
| 50 mM | 0.0721 mL | 0.3607 mL | 0.7214 mL | 1.8036 mL | |
| 60 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5030 mL | |
| 80 mM | 0.0451 mL | 0.2254 mL | 0.4509 mL | 1.1272 mL | |
| 100 mM | 0.0361 mL | 0.1804 mL | 0.3607 mL | 0.9018 mL |
N-Phthaloyl-L-glutamic acid Related Classifications
HY-W011592 Related Classifications
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- N-Phthaloyl-L-glutamic acid
- 340-90-9
- NO Synthase
- BALB/c mice spleen cell culture
- inflammation
- human tumor cell lines
- carrageenan-induced air pouch model
- anti-oral inflammatory agent
- LPS-induced nitric oxide production
- murine spleen cells
- tumor cells
- N-phthaloyl amino acid
- nitric oxide production
- anti-oral inflammatory activity
- PMNL infiltration inhibition
- BALB/c mice
- lipopolysaccharide-induced nitric oxide production inhibitor
- PMNL migration
- Inhibitor
- inhibitor
- inhibit