2. Immunology/Inflammation
  3. NO Synthase
  4. N-Phthaloyl-L-glutamic acid

N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation.

For research use only. We do not sell to patients.

N-Phthaloyl-L-glutamic acid

N-Phthaloyl-L-glutamic acid Chemical Structure

CAS No. : 340-90-9

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Based on 1 publication(s) in Google Scholar

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N-Phthaloyl-L-glutamic acid Related Antibodies

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Description

N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation[1].

In Vitro

N-Phthaloyl-L-glutamic acid (compound 2f) (25-50 μg/mL; 72 h) inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production and shows low cytotoxicity against spleen cell BALB/c mice[1].
N-Phthaloyl-L-glutamic acid (25 μg/mL; 48 h) exhibits weak antiproliferative activity against MDA/MB-435, HCT-8, and SF-295 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Phthaloyl-L-glutamic acid Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA/MB-435, HCT-8, SF-295
Concentration: 25 μg/mL
Incubation Time: 48 h
Result: Inhibited proliferation of MDA/MB-435 cells by 12.92%, HCT-8 cells by 6.52%, and SF-295 cells by 14.42%.
In Vivo

N-Phthaloyl-L-glutamic acid (compound 2f) (100 mg/kg; p.o.; single dose) inhibits predominantly neutrophilic leukocytes (PMNL) migration in BALB/c mice (carrageenan-induced air pouch model) (with a PMNL infiltration inhibition of 61.7%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (weight 25-30 g) (carrageenan-induced air pouch model)[1]
Dosage: 100 mg/kg
Administration: p.o.; single dose
Result: Reduced polymorphonuclear leukocyte migration into the air pouch, resulting in 61.7% inhibition of PMNL infiltration.
Molecular Weight

277.23

Formula

C13H11NO6
CAS No.
Appearance

Solid

SMILES

[C@H](CCC(O)=O)(C(O)=O)N1C(=O)C=2C(C1=O)=CC=CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (420.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6071 mL 18.0356 mL 36.0711 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6071 mL 18.0356 mL 36.0711 mL 90.1778 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL 18.0356 mL
10 mM 0.3607 mL 1.8036 mL 3.6071 mL 9.0178 mL
15 mM 0.2405 mL 1.2024 mL 2.4047 mL 6.0119 mL
20 mM 0.1804 mL 0.9018 mL 1.8036 mL 4.5089 mL
25 mM 0.1443 mL 0.7214 mL 1.4428 mL 3.6071 mL
30 mM 0.1202 mL 0.6012 mL 1.2024 mL 3.0059 mL
40 mM 0.0902 mL 0.4509 mL 0.9018 mL 2.2544 mL
50 mM 0.0721 mL 0.3607 mL 0.7214 mL 1.8036 mL
60 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5030 mL
80 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1272 mL
100 mM 0.0361 mL 0.1804 mL 0.3607 mL 0.9018 mL
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N-Phthaloyl-L-glutamic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Phthaloyl-L-glutamic acid340-90-9NO SynthaseNitric oxide synthasesNOSBALB/c mice spleen cell cultureinflammationhuman tumor cell linescarrageenan-induced air pouch modelanti-oral inflammatory agentLPS-induced nitric oxide productionmurine spleen cellstumor cellsN-phthaloyl amino acidnitric oxide productionanti-oral inflammatory activityPMNL infiltration inhibitionBALB/c micelipopolysaccharide-induced nitric oxide production inhibitorPMNL migrationInhibitorinhibitorinhibit

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