2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase
  5. eNOS Isoform

eNOS

Endothelial NOS (eNOS), also known as NOS3 or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. NOS is localized to the endothelium and is essential for vasodilation and control of blood pressure. NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation. Therefore, a functional eNOS is essential for a healthy cardiovascular system.It is well-established that eNOS is a calmodulin dependent enzyme. eNOS is activated by elevation of intracellular calcium and subsequent activation of CaM-binding domain by calmodulin.

eNOS Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-N0455
    L-Arginine
    		Activator ≥98.0%
    L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO.
  • HY-18732A
    L-NMMA acetate
    		Inhibitor 98.58%
    L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3.
  • HY-152536
    iNOS inhibitor-10
    		Inhibitor
    iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM).