159190-44-0
159190-44-0
Chemical Structure
L-NIO dihydrochloride
- CAS No.: 159190-44-0
- Formula:C7H17Cl2N3O2
- Molecular Weight:246.13
IUPAC Name: (S)-5-acetimidamido-2-aminopentanoic acid dihydrochloride
InChIKey: RYCMAAFECCXGHI-ILKKLZGPSA-N
SMILES: N[C@@H](CCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl
Biological Activity: L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-NIO dihydrochloride | 99.17% | L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. | ||||||||||||||||||||
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References
- [1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
- [2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. [Content Brief]
