TIGIT Protein
T cell immunoglobulin and ITIM domain (TIGIT), also called WUCAM, Vstm3 and VSIG9, is a 244-amino acid transmembrane glycoprotein that expressed by lymphocytes, particularly in effector and regulatory CD4+ T cells, follicular helper CD4+ T cells, effective CD8+ T cells and NK cells. TIGIT is a member of the CD28 family and functions as a co-inhibitory receptor. TIGIT consists of one extracellular immunoglobulin variable region (IgV), a transmembrane domain and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. TIGIT binds to CD155 (PVR, Necl5 or Tage4) with a high-affinity and also to CD112 (PVRL2 or nectin 2) and CD113 (PVRL3) with lower affinity. TIGIT potently inhibits innate and adaptive immunity through multiple mechanisms and is crucial for balancing T cell activation and for protection from autoimmunity.
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TIGIT Protein Recombinant Proteins (22)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
