2. Recombinant Proteins
  3. Receptor Proteins
  4. Notch family

Notch family

Notch family

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The Notch receptors are evolutionarily highly conserved single-pass transmembrane proteins that normally communicate signals upon binding to transmembrane ligands expressed on adjacent cells. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1, DLL3, and DLL4. All of Notch receptors have an extracellular domain containing multiple epidermal growth factor (EGF)-like repeats and an intracellular region containing the RAM domain, ankyrin repeats, and a C-terminal PEST domain. Notch receptors function in highly conserved intercellular signaling pathway, which is highly conserved from Drosophila to humans, and play an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies, including leukemia, glioblastoma and lung and breast cancers.

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