1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT

GlyT

Glycine transporters (GlyTs) belong to a large family of Na+/Cl--dependent transporter proteins that includes transporters for monoamines [5-hydroxytryptamine (serotonin), noradrenaline and dopamine] and γ-aminobutyric acid. GlyT-mediated glycine uptake is energetically coupled with the transmembrane sodium gradient maintained by the Na+/K+-ATPase.

GlyT1 is essential for regulating glycine concentrations at synaptic receptors.

GlyT2 is uniquely designed for neurotransmitter recycling at inhibitory glycinergic synapses, and loss of GlyT2 function generates a severely hyperexcited state.

GlyT Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-10809
    Bitopertin Inhibitor 99.75%
    Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.
  • HY-18723
    GlyT2-IN-1 Inhibitor
    GlyT2-IN-1 is a glycine transporters GLYT2 inhibitor.
  • HY-100416A
    LY2365109 hydrochloride Inhibitor 98.83%
    LY2365109 is a potent and selective GlyT1 inhibitors with IC50 value of 15.8 nM.
  • HY-10809A
    Bitopertin R enantiomer Inhibitor
    Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.