Complement Component 7
Complement component 7 (C7) is a terminal-pathway glycoprotein that couples C5b-6 formation to membrane attack complex insertion. Structurally, C7 resembles C6 and C9 in containing thrombospondin type 1, LDL-receptor class A, and EGF-like modules, with a key amphipathic domain that, after C7 binds the C5b-6 complex, unfolds and penetrates the lipid bilayer to anchor the growing MAC. C7 then recruits C8, which initiates polymerization of C9. Congenital C7 deficiency is among the better-characterized terminal complement defects and, like C5 through C9 deficiencies, markedly increases the risk of recurrent Neisseria meningitidis infection, particularly in genetically susceptible populations.
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Complement Component 7 Recombinant Proteins (2)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
