1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Related Products (71):

Cat. No. Product Name Effect Purity
  • HY-15084
    (+)-MK 801 Maleate Antagonist 99.98%
    (+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
  • HY-12506
    Naspm Inhibitor
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
  • HY-17551
    NMDA Agonist >98.0%
    NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
  • HY-12882A
    Ifenprodil tartrate Antagonist 99.69%
    Ifenprodil tartrate is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that selectively inhibits receptors containing the NR2B subunit.
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
  • HY-N2370
    24-Hydroxycholesterol Activator >98.0%
    24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-B1333
    Dextromethorphan hydrobromide hydrate Antagonist 99.76%
    Dextromethorphan hydrobromide hydrate is an antitussive drug.
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX is a AMPA receptor antagonists.
  • HY-15084A
    (-)-MK 801 Maleate 99.70%
    (-)-MK 801 Maleate is the enantiomer of (+)-MK-801.
  • HY-16312
    MDL-29951 Antagonist 98.50%
    MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
  • HY-16713A
    (S)-(-)-5-Fluorowillardiine hydrochloride Agonist
    (S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist.
  • HY-17001
    Flupirtine Maleate Antagonist 99.93%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor 98.49%
    Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
  • HY-12505
    CX546 Agonist 99.50%
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
  • HY-16728
    Rapastinel Modulator 99.49%
    Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.
  • HY-10934
    LY451395 Activator 99.47%
    LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-17550
    Sunifiram Agonist 99.82%
    Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.
  • HY-15079
    Talampanel Antagonist 98.50%
    Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).