1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Related Products (117):

Cat. No. Product Name Effect Purity
  • HY-15084
    Dizocilpine Antagonist 99.98%
    Dizocilpine (MK-801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
  • HY-100714A
    D-AP5 Antagonist
    D-AP5 is a NMDA receptor antagonist.
  • HY-17551
    NMDA Agonist >98.0%
    NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
  • HY-12882A
    Ifenprodil tartrate Antagonist 98.87%
    Ifenprodil tartrate is the atypical noncompetitive NMDA receptor antagonist and inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50=0.34 μM). Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors over 400-fold than at NR1A/NR2A receptors(IC50=146 μM). Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator.
  • HY-107702
    CGP 37849 Antagonist >99.0%
    CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects.
  • HY-15084B
    Dizocilpine free base Antagonist
    Dizocilpine, a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
  • HY-110234
    Topiramate D12 Antagonist
    Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
  • HY-15069
    Fanapanel Antagonist 99.93%
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine (hydrochloride) (D-145 (hydrochloride)), an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-15068
    NBQX Antagonist 99.99%
    NBQX is a highly selective and competitive AMPA receptor antagonist.
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
  • HY-15067
    DNQX Antagonist 98.45%
    DNQX (FG 9041) is a AMPA receptor antagonists.
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor
    Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
  • HY-N0215
    L-Phenylalanine Antagonist 98.06%
    L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
  • HY-Y0966
    Glycine >98.0%
    Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
  • HY-15084A
    (-)-Dizocilpine 99.84%
    (-)-Dizocilpine ((-)-MK-801) is the enantiomer of (+)-MK-801. (+)-MK-801 is a potent, selective and non-competitive NMDA receptor antagonist.
  • HY-P0117
    Tat-NR2B9c Inhibitor 98.22%
    Tat-NR2B9c (NA-1) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1. Tat-NR2B9c also reduces NMDA-induced p38 activation, inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.
  • HY-14608A
    L-Glutamic acid monosodium salt Agonist >98.0%
    L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
  • HY-W018061
    Traxoprodil Antagonist 99.43%
    Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Isoform Specific Products

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