1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Related Products (59):

Cat. No. Product Name Effect Purity
  • HY-15084
    (+)-MK 801 (Maleate) Antagonist 99.94%
    Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM IC50 Value: 30.5 nM[1].
  • HY-12506
    Naspm Inhibitor
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
  • HY-16312
    MDL-29951 Antagonist 98.50%
    MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
  • HY-B1333
    Dextromethorphan hydrobromide hydrate Antagonist 99.76%
    Dextromethorphan hydrobromide hydrate is an antitussive drug.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-10937
    Farampator Modulator
    Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
  • HY-101216
    Org-26576 Modulator 99.81%
    Org 26576 is a AMPA receptor positive allosteric modulator.
  • HY-17551
    NMDA Agonist >98.0%
    NMDA(N-Methyl-D-aspartic acid) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
  • HY-12882A
    Ifenprodil tartrate Antagonist 99.69%
    Ifenprodil tartrate is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that selectively inhibits receptors containing the NR2B subunit.
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 99.82%
    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
  • HY-16713A
    (S)-(-)-5-Fluorowillardiine hydrochloride Agonist
    (S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist.
  • HY-15084A
    (-)-MK 801 Maleate 99.70%
    (-)-MK 801 Maleate is the enantiomer of (+)-MK-801.
  • HY-12505
    CX546 Agonist
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
  • HY-10934
    LY451395 Activator 99.47%
    LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX is a AMPA receptor antagonists.
  • HY-17001
    Flupirtine Maleate Antagonist 99.93%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
  • HY-12506A
    Naspm trihydrochloride Inhibitor >98.0%
    Naspm 3Hcl(1-Naphthylacetyl spermine) is a potent and selective Ca2+ permeable AMPA receptor(Ca-perm AMPAR) blocker.
  • HY-10935
    LY450108 Activator
    LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.
  • HY-10932
    Aniracetam Modulator 99.43%
    Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
  • HY-17550
    Sunifiram Agonist 99.82%
    Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.