1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Related Products (94):

Cat. No. Product Name Effect Purity
  • HY-15084
    Dizocilpine Maleate Antagonist 99.98%
    Dizocilpine ((+)-MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
  • HY-17551
    NMDA Agonist >98.0%
    NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
  • HY-12882A
    Ifenprodil tartrate Antagonist
    Ifenprodil tartrate is a NR2B subunit selective NMDA receptor antagonist with an IC50 of 0.3 μM.
  • HY-100714A
    D-AP5 Antagonist >98.0%
    D-AP5 is a NMDA receptor antagonist.
  • HY-P1594A
    Dynorphin A (1-10) TFA Inhibitor
    Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.
  • HY-109046
    Tulrampator Agonist 99.40%
    Tulrampator (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Antidepressant.
  • HY-107774
    BMS-986163 Modulator
    BMS-986163 is a negative allosteric modulator of GluN2B. The prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX (FG 9041) is a AMPA receptor antagonists.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine (hydrochloride) (D-145 (hydrochloride)), an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor 98.49%
    Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
  • HY-15084A
    (-)-Dizocilpine Maleate 99.70%
    (-)-Dizocilpine ((-)-MK 801) Maleate is the enantiomer of (+)-MK-801. (+)-MK 801 Maleate is a potent, selective and non-competitive NMDA receptor antagonist.
  • HY-17001
    Flupirtine Maleate Antagonist 99.97%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
  • HY-15069
    Fanapanel Antagonist 99.93%
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
  • HY-16312
    MDL-29951 Antagonist 98.50%
    MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
  • HY-12506
    Naspm Inhibitor
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
  • HY-10934
    Mibampator Activator 99.47%
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-12505
    CX546 Agonist 99.50%
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
  • HY-15079
    Talampanel Antagonist 98.59%
    Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.