1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Related Products (90):

Cat. No. Product Name Effect Purity
  • HY-15084
    Dizocilpine Maleate Antagonist 99.98%
    (+)-MK 801 Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
  • HY-17551
    NMDA Agonist >98.0%
    NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
  • HY-12882A
    Ifenprodil tartrate Antagonist
    Ifenprodil tartrate is a NR2B subunit selective NMDA receptor antagonist with an IC50 of 0.3 μM.
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
  • HY-102053
    Apimostinel Agonist
    Apimostinel is an oral NMDA receptor partial agonist.
  • HY-Y0966
    Glycine >98.0%
    Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
  • HY-P1594A
    Dynorphin A (1-10) TFA Inhibitor
    Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX is a AMPA receptor antagonists.
  • HY-100714A
    D-AP5 Antagonist >98.0%
    D-AP5 is a NMDA receptor antagonist.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor 98.49%
    Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
  • HY-15084A
    (-)-Dizocilpine Maleate 99.70%
    (-)-MK 801 Maleate is the enantiomer of (+)-MK-801. (+)-MK 801 Maleate is a potent, selective and non-competitive NMDA receptor antagonist.
  • HY-17001
    Flupirtine Maleate Antagonist 99.97%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
  • HY-15079
    Talampanel Antagonist 98.59%
    Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).
  • HY-12506
    Naspm Inhibitor
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
  • HY-10934
    Mibampator Activator 99.47%
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-12505
    CX546 Agonist 99.50%
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
  • HY-17555
    Meclofenoxate hydrochloride Activator
    Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
  • HY-12506A
    Naspm trihydrochloride Inhibitor >98.0%
    Naspm (1-Naphthyl acetyl spermine) trihydrochloride, a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.