1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CNQX

CNQX (Synonyms: FG9065)

Cat. No.: HY-15066 Purity: 99.65%
Handling Instructions

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

For research use only. We do not sell to patients.

CNQX Chemical Structure

CNQX Chemical Structure

CAS No. : 115066-14-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of CNQX:

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  • Biological Activity

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Description

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].

IC50 & Target

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)[1]

In Vitro

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 180-200 g[4]
Dosage: 0.75, 1.5, and 3 mg/kg
Administration: IP; 20 min before testing
Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval
Molecular Weight

232.15

Formula

C₉H₄N₄O₄

CAS No.
SMILES

O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (107.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (8.96 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.65%

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Keywords:

CNQXFG9065FG 9065FG-9065iGluRIonotropic glutamate receptorsAMPAkainatenon-NMDAfear-potentiatedstartleInhibitorinhibitorinhibit

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CNQX
Cat. No.:
HY-15066
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