1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

CNQX (Synonyms: FG9065)

Cat. No.: HY-15066 Purity: 98.05%
Handling Instructions

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

For research use only. We do not sell to patients.
CNQX Chemical Structure

CNQX Chemical Structure

CAS No. : 115066-14-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
5 mg USD 60 In-stock
10 mg USD 84 In-stock
25 mg USD 168 In-stock
50 mg USD 264 In-stock
100 mg USD 480 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

In Vitro

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].

In Vivo

The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[4]

CNQX is dissolved in DMSO and diluted in physiological saline.

CNQX is applied by injecting a bolus into the input line of the chamber over 60 s using a motorized syringe pump. In a subpopulation of neurons, CNQX is bath applied for 5 min. Control injections of physiological saline or vehicle (DMSO) does not alter membrane potential/input resistance during voltage recordings[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

232.15

Formula

C₉H₄N₄O₄

CAS No.

115066-14-3

SMILES

O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CNQX
Cat. No.:
HY-15066
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