1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

CNQX (Synonyms: FG9065)

Cat. No.: HY-15066 Purity: 98.05%
Handling Instructions

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

For research use only. We do not sell to patients.
CNQX Chemical Structure

CNQX Chemical Structure

CAS No. : 115066-14-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
5 mg USD 60 In-stock
10 mg USD 84 In-stock
25 mg USD 168 In-stock
50 mg USD 264 In-stock
100 mg USD 480 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

In Vitro

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].

In Vivo

The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay

CNQX is dissolved in DMSO and diluted in physiological saline.

CNQX is applied by injecting a bolus into the input line of the chamber over 60 s using a motorized syringe pump. In a subpopulation of neurons, CNQX is bath applied for 5 min. Control injections of physiological saline or vehicle (DMSO) does not alter membrane potential/input resistance during voltage recordings[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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