2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. CNQX

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

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CNQX Chemical Structure

CNQX Chemical Structure

CAS No. : 115066-14-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 9 publication(s) in Google Scholar

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CNQX Related Antibodies

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Description

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].

IC50 & Target

Kainate Receptor

 

In Vitro

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CNQX Related Antibodies
In Vivo

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 180-200 g[4]
Dosage: 0.75, 1.5, and 3 mg/kg
Administration: IP; 20 min before testing
Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval
Molecular Weight

232.15

Formula

C9H4N4O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (86.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (253 KB) HNMR (186 KB) LCMS (83 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3076 mL 21.5378 mL 43.0756 mL 107.6890 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL 21.5378 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL 10.7689 mL
15 mM 0.2872 mL 1.4359 mL 2.8717 mL 7.1793 mL
20 mM 0.2154 mL 1.0769 mL 2.1538 mL 5.3844 mL
25 mM 0.1723 mL 0.8615 mL 1.7230 mL 4.3076 mL
30 mM 0.1436 mL 0.7179 mL 1.4359 mL 3.5896 mL
40 mM 0.1077 mL 0.5384 mL 1.0769 mL 2.6922 mL
50 mM 0.0862 mL 0.4308 mL 0.8615 mL 2.1538 mL
60 mM 0.0718 mL 0.3590 mL 0.7179 mL 1.7948 mL
80 mM 0.0538 mL 0.2692 mL 0.5384 mL 1.3461 mL
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CNQX Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNQX115066-14-3FG9065FG 9065FG-9065iGluRIonotropic glutamate receptorsAMPAkainatenon-NMDAfear-potentiatedstartleInhibitorinhibitorinhibit

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