1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CNQX

CNQX (Synonyms: FG9065)

Cat. No.: HY-15066 Purity: 98.05%
Handling Instructions

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

For research use only. We do not sell to patients.

CNQX Chemical Structure

CNQX Chemical Structure

CAS No. : 115066-14-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE CNQX

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CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

In Vitro

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].

In Vivo

The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (129.23 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.77 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 98.05%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2


CNQXFG9065FG 9065FG-9065iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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