2. Recombinant Proteins
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Ebola Virus Proteins

Ebola Virus Proteins

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Ebola virus (EBOV) is a member of genus Ebolavirus, family Filoviridae that has caused the deadliest Ebola virus disease (EVD). The viral genome is 19 kb long, linear, non-segmented negative sense (NNS), single-stranded RNA, that encoding seven genes: nucleoprotein (NP), viral protein 35 (VP35), VP40, glycoprotein (GP), VP30, VP24, and an RNA-dependent RNA polymerase (L). Each gene, except GP, contains a single open reading frame (ORF). In contrast, the GP gene consists of three overlapping ORFs. During the assembly, viral RNA forms a ribonucleoprotein (RNP) complex with NP, L, VP30, VP35 and VP24, which appears as a helical nucleocapsid (NC). NC protects the viral RNA from degradation by endonucleases and hosts immune response.

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