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Ebola virus (EBOV) is a member of genus Ebolavirus, family Filoviridae that has caused the deadliest Ebola virus disease (EVD). The viral genome is 19 kb long, linear, non-segmented negative sense (NNS), single-stranded RNA, that encoding seven genes: nucleoprotein (NP), viral protein 35 (VP35), VP40, glycoprotein (GP), VP30, VP24, and an RNA-dependent RNA polymerase (L). Each gene, except GP, contains a single open reading frame (ORF). In contrast, the GP gene consists of three overlapping ORFs. During the assembly, viral RNA forms a ribonucleoprotein (RNP) complex with NP, L, VP30, VP35 and VP24, which appears as a helical nucleocapsid (NC). NC protects the viral RNA from degradation by endonucleases and hosts immune response.
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Makona-Kissidougou-C15) GP / Glycoprotein Protein
Virus
HEK293
Ebola virus Glycoprotein/GP Protein is pivotal in viral entry, serving as the receptor-binding subunit.In later infection stages, GP1 down-regulates crucial host cell surface molecules, including integrins like ITGA1-6, disrupting adhesion and potentially causing blood vessel integrity disruption.GP1 interacts with host TLR4, stimulating monocyte differentiation, leading to T-lymphocyte bystander death.It down-regulates natural killer cell function, counters BST2/tetherin, cooperates with VP40 for NF-kappa-B activation, acts as an antibody decoy, and induces cytokine transcription in host macrophages and dendritic cells through TLR4 activation.Ebola virus Glycoprotein/GP Protein (QDA39862, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by HEK293 , with C-His labeled tag.
Ebola virus EBOV (subtype Sudan, strain Gulu) GP / Glycoprotein Protein
Virus
HEK293
Ebola virus glycoprotein (GP1), as a receptor-binding subunit, plays a key role in the virus entry process. During late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, disrupting adhesion and potentially leading to disruption of vascular integrity. Ebola virus Glycoprotein/GP Protein (Q7T9D9, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by HEK293 , with C-His labeled tag.
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion.GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity.Ebola virus Glycoprotein/GP Protein (AIE11917, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by HEK293 , with C-His labeled tag.
The Ebola virus NP/nucleoprotein is critical for viral genome protection and replication, forming a helical capsid to protect the genome. The VP35 interaction stabilizes the monomeric NP, maintaining solubility until replication triggers cooperative binding to viral RNA. Ebola virus NP/Nucleoprotein Protein (109a.a, Q5XX08, His) is the recombinant Virus-derived Ebola virus NP/Nucleoprotein protein, expressed by E. coli , with N-His labeled tag.
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion. GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity. Ebola virus Glycoprotein/GP Protein RBD (AHX24649, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein RBD, expressed by HEK293 , with C-His labeled tag.
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Matrix protein VP40 Protein (His)
Virus
E. coli
Ebola virus VP40 (matrix VP40 protein) centrally directs virus assembly and budding and has complex interactions with viral ribonucleocapsid and host ESCRT proteins (VPS4, PDCD6IP/ALIX, NEDD4, TGS101). Ebola virus VP40/Matrix VP40 Protein (AHX24648, His) is the recombinant Virus-derived Ebola virus VP40/Matrix VP40 protein, expressed by E. coli , with N-6*His labeled tag.
Ebola virus EBOV (subtype Sudan, strain Gulu) VP40 / Matrix protein VP40 Protein (His)
Virus
E. coli
Ebola virus VP40 (matrix VP40 protein) centrally directs virus assembly and budding and has complex interactions with viral ribonucleocapsid and host ESCRT proteins (VPS4, PDCD6IP/ALIX, NEDD4, TGS101). Ebola virus VP40/Matrix VP40 Protein (Q5XX06, His) is the recombinant Virus-derived Ebola virus VP40/Matrix VP40 protein, expressed by E. coli , with N-His labeled tag.
Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP Protein (His)
Virus
Sf9 insect cells
Ebola virus glycoprotein (GP1), as a receptor-binding subunit, plays a key role in the virus entry process. During late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, disrupting adhesion and potentially leading to disruption of vascular integrity. Ebola virus Glycoprotein/GP Protein (Q7T9D9, sf9, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by Sf9 insect cells , with C-His labeled tag.
Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP Protein (His)
Virus
Sf9 insect cells
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion. GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity. Ebola virus Glycoprotein/GP Protein (Q05320, sf9, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by Sf9 insect cells , with C-His labeled tag.
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP Protein (His)
Virus
Sf9 insect cells
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion.GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity.Ebola virus Glycoprotein/GP Protein (AHX24649, sf9, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by Sf9 insect cells , with C-His labeled tag.
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP (Virion spike glycoprotein) Protein (His)
Virus
HEK293
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion.GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity.Ebola virus Glycoprotein/GP Protein (AHX24649, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP protein, expressed by HEK293 , with C-His labeled tag.
Ebola virus glycoprotein (GP1), as a receptor-binding subunit, plays a key role in the virus entry process. During late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, disrupting adhesion and potentially leading to disruption of vascular integrity. Ebola virus Glycoprotein/GP1 Protein (ACI28624, sf9, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) VP40 / Matrix protein VP40 Protein (His)
Virus
E. coli
Ebola virus VP40/Matrix VP40 Protein is essential for assembling and budding virus particles, interacting with host proteins linked to the multivesicular body pathway. Ebola virus VP40/Matrix VP40 Protein (B8XCM9, His) is the recombinant Virus-derived Ebola virus VP40/Matrix VP40 protein, expressed by E. coli , with N-His labeled tag.
Ebola virus glycoprotein (GP1), as a receptor-binding subunit, plays a key role in the virus entry process. During late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, disrupting adhesion and potentially leading to disruption of vascular integrity. Ebola virus Glycoprotein/GP1 Protein (468a.a, Q7T9D9, sf9, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Ebola virus glycoprotein (GP1), as a receptor-binding subunit, plays a key role in the virus entry process. During late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, disrupting adhesion and potentially leading to disruption of vascular integrity. Ebola virus Glycoprotein/GP1 Protein (468a.a, Q7T9D9, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP1 protein, expressed by HEK293 , with C-His labeled tag.
Ebola virus EBOV (subtype Sudan, strain Gulu) VP40 / Matrix protein VP40 Protein (His-MBP)
Virus
E. coli
Ebola virus VP40 (matrix VP40 protein) centrally directs virus assembly and budding and has complex interactions with viral ribonucleocapsid and host ESCRT proteins (VPS4, PDCD6IP/ALIX, NEDD4, TGS101). Ebola virus VP40/Matrix VP40 Protein (YP_138522, His-MBP) is the recombinant Virus-derived Ebola virus VP40/Matrix VP40 protein, expressed by E. coli , with N-His, N-MBP labeled tag.
Ebola virus glycoproteins (GPs) play a key role in the virus entry process, with GP1 serving as the receptor-binding subunit and GP2 for membrane fusion.GP downregulates host cell surface molecules, disrupts adhesion and may lead to disruption of vascular integrity.Ebola virus Glycoprotein/GP1 Protein (AHX24649, HEK293, His) is the recombinant Virus-derived Ebola virus Glycoprotein/GP1 protein, expressed by HEK293 , with C-His labeled tag.
The Ebola virus NP/nucleoprotein is critical for viral genome protection and replication, forming a helical capsid to protect the genome.The VP35 interaction stabilizes the monomeric NP, maintaining solubility until replication triggers cooperative binding to viral RNA.Ebola virus NP/Nucleoprotein Protein (His) is the recombinant Virus-derived Ebola virus NP/Nucleoprotein protein, expressed by E.coli , with N-His labeled tag.
The Ebola virus NP/nucleoprotein is critical for viral genome protection and replication, forming a helical capsid to protect the genome. The VP35 interaction stabilizes the monomeric NP, maintaining solubility until replication triggers cooperative binding to viral RNA. Ebola virus NP/Nucleoprotein Protein (378a.a, Q5XX08, His) is the recombinant Virus-derived Ebola virus NP/Nucleoprotein protein, expressed by E. coli , with N-His labeled tag.
