Siglec-6
Siglec-6 (CD327) is a sialic acid binding immunoglobulin-type lectin characterized by one V-set Ig domain and two C2-set domains, with a cytoplasmic tail containing tyrosine-based inhibitory motifs. Originally cloned as OB-BP1 for its reported ability to bind the hormone leptin, Siglec-6 is expressed on B cells, placental trophoblasts, and mast cells, and it recognizes sialyl-Tn and related alpha2,6-sialylated glycans. Elevated placental Siglec-6 has been associated with preeclampsia, and its presence on certain leukemia and mast cell populations has prompted interest in Siglec-6-targeted antibody approaches. Siglec-6 shares close sequence homology with CD33 but differs in expression pattern.
